LETTER

JOP. J Pancreas (Online) 2015 Mar 20; 16(2):213.

Comments on “Risk Factors Associated with Recurrence in Patients with Solid Pseudopapillary Tumors of the Pancreas”

Xing Wang, Xubao Liu

Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University. Chengdu, China

Dear Editor,

We read with interest the article by Pablo et al. [1]. We appreciate that they shared their experience in risk factors associated with recurrence in patients with solid-pseudopapillary tumor (SPT) of the pancreas; however, we have several concerns regarding their study.

The authors stated that, lymphovascular invasion (P=0.04) was one of the risk factors associated with recurrence. Nevertheless, there was only one lymphovascular invasion detected in SPT cases either with recurrences (1/3) or without recurrences (1/29). Additionally, Jeannelyn et al. showed the different result (P=0.10) regarding lymphovascular invasion as one of the risk factors associated with recurrence in their study, which concerns 64 patients with SPT (including at least 6 patients with lymphovascular invasion, 6/64) [2]. Due to the scarcity of patients with lymphovascular invasion in the author’s present study, it may be difficult to establish a definite conclusion that patients who developed recurrences more commonly had lymphovascular invasion.

They also stated that there were 3 patients out of 32 (9.4%) who suffered recurrence. The rate of recurrence of SPT was much lower in the other two larger series reported by Kim et al. (2/106, 1.9%) and our institution (2/115, 1.7%) [3, 4]. Given the relative small size of sample, the demographic distribution of SPT in their study may prevent them from making a persuasive conclusion.

In addition, based on the 2010 WHO histological criteria [5], Kim et al. reported that 17 patients out of 106 (16%) had a SPN with histological findings of high-grade malignancy [3]. Furthermore, all the 2 patients of recurrence of SPT were of high-grade malignancy. In your opinions, does the degree of malignancy play a role as a risk factor of recurrence of SPT?

Overall, we agree with Pablo et al. that lymphovascular invasion may be associated with aggressive behavior. However, in our point of view, whether SPT with lymphovascular invasion are associated with higher risk of recurrence needs further study.

Received December 14th, 2014 – Accepted January 26th, 2015

Keywords Pancreas; Pancreas, Exocrine; Pancreatectomy; Pancreatic Neoplasms

Conflict of Interest Authors declare to have no conflict of interest

Correspondence Xubao Liu
No 37, Guo Xue Xiang
Chengdu
Sichuan, 610041
China
Phone: +86-28-85422477
Fax: +86-28-85422474
E-mail: abc_1030@163.com

References

1. Serrano PE, Serra S, Al-Ali H, Gallinger S, Greig PD, McGilvray ID, Moulton CA. et al., Risk Factors Associated with Recurrence in Patients with Solid Pseudopapillary Tumors of the Pancreas. JOP : Journal of the pancreas. 2014; 15: 561-568. [PMID: 25435571]

2. Estrella JS, Li L, Rashid A, et al. Solid pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. The American journal of surgical pathology. 2014; 38:147-157. [PMID: 24418850]

3. Kim MJ, Choi DW, Choi SH, et al. Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy. British Journal of Surgery. 2014; 101:1266-1271. [PMID: 25052300]

4. Cai Y, Ran X, Xie S, et al. Surgical management and long-term follow-up of solid pseudopapillary tumor of pancreas: a large series from a single institution. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2014; 18: 935-940. [PMID: 24519038]

5. Bosman FT, Carneiro F, Hruban RH, et al. WHO Classifiation of Tumours of the Digestive System. International Agency for Research on Cancer: Lyon, 2010. [NLMID: 01553728]