JOP. J Pancreas (Online) 2012 Jan 10; 13(1):87-90.



Acinar Cell Carcinoma of the Pancreas: A Possible Role of S-1 as Chemotherapy for Acinar Cell Carcinoma. A Case Report



Tameyoshi Yamamoto, Hiroki Ohzato, Mutumi Fukunaga, Hiroshi Imamura, Hiroshi Furukawa



Department of Surgery, Sakai Municipal Hospital. Sakai, Osaka, Japan




Context Acinar cell carcinoma of the pancreas is a rare malignancy, accounting for 1-2% of pancreatic exocrine malignancies. This rarity makes it difficult to standardize a protocol of treatment for acinar cell carcinoma. Case report A 71-year-old male without any particular past history was referred to our institute with abdominal distention and mild liver dysfunction. Computed tomography (CT) revealed a cystic lesion with a diameter of 3.5 cm, which originated from the neck of pancreas and had solid nodules inside. Several nodules were demonstrated surrounding the cystic tumor. Laparotomy and histological study demonstrated peritoneal dissemination of acinar cell carcinoma. The patient was treated with S-1 monotherapy (80 mg/m2 for four weeks with a two-week interval as one cycle). After one cycle of S-1 monotherapy, CT demonstrated remarkable shrinkage of the main tumor and disappearance of the nodules on the peritoneum. The patient underwent a radical distal pancreatectomy. The patient was then treated with 16 cycles of S-1 monotherapy after the radical pancreatectomy and remains without any recurrence of the disease two years later. Conclusion Initially inoperable acinar cell carcinoma was treated by monotherapy using S-1, resulting in curative operation and two years disease free survival post operation. S-1 might be more effective on acinar cell carcinoma, rather than gemcitabine.





Acinar cell carcinoma of the pancreas is a rare malignancy, accounting for 1-2% of pancreatic exocrine malignancies [1, 2]. This rarity makes it difficult to standardize a protocol of treatment for it.

At the time of diagnosis, 38.5 to 76.5% of patients with acinar cell carcinoma have been considered as resectable [3, 4, 5]. The median overall survival of patients with unresectable acinar cell carcinoma is about 3 to 27 months [4, 5]. Resectable acinar cell carcinoma has been treated by the standard radical pancreatectomy, resulting in a 5-year survival rate of 36.2 to 42.8% [3, 5]. There have been a few large-scale clinical studies on the surgical outcomes of acinar cell carcinoma. Memorial Sloan-Kettering Cancer Center [5] reported a surgical outcome of acinar cell carcinoma that was between those of endocrine and ductal adenocarcinomas. In 2007, Kitagami et al. [4] reported a similar result of acinar cell carcinoma by analyzing 115 patients from the Pancreatic Cancer Registry of the Japan Pancreas Cancer Society. Although the resection rate and 5-year survival varied depending on the paper, these retrospective studies indicated that surgical resection can be postulated as the first-line treatment for acinar cell carcinoma. Acinar cell carcinoma might often recur in the liver and locoregional region, even if the resection rate was relatively high in comparison with that of ductal adenocarcinoma [4, 6].

In order to improve the clinical outcome of acinar cell carcinoma, chemotherapy and/or radiation therapy might be necessary. Although the chemo- and/or radio-therapy group showed a better outcome than surgery alone group in the retrospective studies [4, 6], these data might include clinical bias. The efficacy and protocol of the adjuvant therapies have not been examined by large-scale clinical studies. The standard protocol of chemotherapy for acinar cell carcinoma has not been established.

We report here a patient with initially unresectable acinar cell carcinoma who underwent chemotherapy using S-1 and radical operation.




A 71-year-old male was referred with a chief complaint of abdominal distention and a mild elevation of transaminase in December 2008. CT demonstrated a cystic lesion with a diameter of 3.5 cm, which originated from the neck of the pancreas and had solid nodules inside. Several well-enhanced nodules were observed surrounding the main tumor (Figure 1ab). The main pancreatic duct was not dilated. A small amount of ascites was shown, which was preoperatively controlled with diuretics. Positron emission tomography showed no abnormal uptake, which is considered to indicate that it was unresectable (data not shown).



Figure 1. CT scan prior to (a. b.) and during chemotherapy (c.), and prior to operation (d.).



The patient was diagnosed with an intraductal papillary mucinous carcinoma with lymph-node metastasis, and underwent an operation. Laparotomy presented the cystic tumor and white-colored nodules on the surface of the transverse mesocolon (Figure 2a), which was histologically diagnosed as acinar cell carcinoma (Figure 3ab) and deemed unresectable.



Figure 2. a. Findings of the main tumor and the surrounding nodules in the first operation, and (b.) macroscopic appearances of the resected tissues and the transection of the main tumor.



Figure 3. Histological studies of the peritoneal nodules in the first operation (a. b.) and induration in the second operation (c. d.).



S-1 was used as palliative chemotherapy. 80 mg/m2 per day was given to the patient for 4 weeks with a break of two weeks as a cycle. After one cycle of S-1 monotherapy, CT scan showed remarkable shrinkage of the main tumor and peritoneal dissemination (Figure 1c). This effect demonstrated by CT scan continued until four courses of S-1 administration over five cycles (Figure 1d). In addition, chemotherapy was well tolerated and no severe complications were observed. We decided upon operative re-exploration with the aim of radical resection.

In the second-look operation, there was no lesion that was deemed unresectable. The disseminations on the transverse mesocolon had disappeared, and the cystic main tumor had shrunk to the induration on the surface of the pancreas with a size of 8x4 mm. This lesion was excised and subjected to histological study, which demonstrated a small nest of cancer cells in the granulation tissue (Figure 3cd), which suggested a grade 2 effect of chemotherapy. Distal pancreatectomy was performed with lymph node dissection as well as ductal adenocarcinoma and resection of the transverse mesocolon (Figure 2b). There was no other microscopic finding except for remarkable infiltration of macrophages into the lymph node. Immunohistochemically, the tumor cells were positive for trypsin, lipase, and chymotrypsin, which are specific for acinar cell carcinoma.

Postoperative surgical complications did not occur. After a two-week hospital stay, the patient was discharged. From six weeks after the second-look operation, 80 mg/m2 S-1 was administered for two weeks with a one-week interval as a cycle. While chemotherapy transiently ceased because of subileus, 16 cycles of S-1 monotherapy were completed following the second-look operation. Thereafter, the dose of S-1 was decreased 20% owing to mild renal dysfunction and 3 cycles were carried out. The disease did not recur for two years after the second-look operation without any deterioration of the general condition of the patient.




Acinar cell carcinoma is a rare disease comprising 1% of malignant tumors originating from pancreatic exocrine tissues [1, 2, 3, 4, 5, 6]. Postoperative survival and resection rates of acinar cell carcinoma have been reported to be superior to those of pancreatic ductal adenocarcinoma, but were not satisfactory. Adjuvant therapy might be needed to improve the clinical outcome of acinar cell carcinoma. Until gemcitabine and S-1 were proven to be effective for pancreatic ductal adenocarcinoma, various anti-cancer drugs have been used for acinar cell carcinoma [7; 8, 9, 10, 11]. Thereafter, gemcitabine and/or S-1 might be clinically used for rare pancreatic malignancies including acinar cell carcinoma, undifferentiated adenocarcinoma, and pancreatoblastoma, as well as for pancreatic ductal adenocarcinoma. However, the effectiveness of these two drugs for these tumors has remained unclear.

Gemcitabine has a crucial role as an anti-cancer drug for pancreatic ductal adenocarcinoma. The effectiveness of gemcitabine has been reported in palliative [12] and adjuvant settings [13]. Sorscher et al. reported a case with metastatic acinar cell carcinoma successfully treated with gemcitabine, 5-fluorouracil (5-FU), and leucovorin [14]. On the other hand, Seki et al. reported that monotherapy with gemcitabine was ineffective in four cases with acinar cell carcinoma [15]. We have experienced five cases of acinar cell carcinoma, in which gemcitabine monotherapy failed in two (data not shown).

S-1 is an orally administered drug that is comprised of the 5-FU prodrug tegafur and two molecules, gimeracil and oteracil potassium, which increase the blood concentration, alleviate the gastrointestinal toxicity of 5-FU, and enhance the anti-tumor effect of 5-FU [16]. Clinical studies using S-1 have proven a significant anti-tumor activity in a variety of the malignant tumors: stomach cancer, colorectal cancer, head and neck cancer, non-small cell lung cancer, and breast cancer. An early phase II study of pancreatic ductal adenocarcinoma with distant metastasis demonstrated a response rate of 21.1%, time to progression of 77 days, and mean survival time of 169 days [17]. Another phase II study showed a response rate of 37.5%, time to progression of 113 days, and mean survival time of 281 days [18]. The above data led to the approval of S-1 for the treatment of pancreatic ductal adenocarcinoma in Japan in August 2006.

Recently, several case reports revealed successful control of acinar cell carcinoma using S-1 in Japan. Seki et al. reported four patients who were successfully treated with S-1 after failure of gemcitabine monotherapy [15]. Besides S-1 monotherapy, S-1 plus gemcitabine or cis-diamminedichloroplatinum (CDDP) combination therapy has been reported. Among these reports, main tumor or liver metastasis responded to chemotherapy. Lee reported that locally advanced acinar cell carcinoma of the pancreas was successfully treated by capecitabine and concurrent radiotherapy [9]. S-1 and capecitabine are 5-FU prodrugs. These findings suggest that 5-FU might be effective for acinar cell carcinoma, while gemcitabine might not. This was the reason why S-1 was chosen for the patient reported in this paper. In our patient, main tumor and peritoneal dissemination responded to S-1 monotherapy. In addition, these lesions remarkably and rapidly shrank.

In conclusion, we experienced successful control of acinar cell carcinoma accompanied by peritoneal dissemination using S-1, resulting in radical resection and 2-year disease free survival. S-1 might be effective for acinar cell carcinoma, even for the far advanced stage of acinar cell carcinoma, as preoperative chemotherapy.



Received November 10th, 2011 - Accepted November 20th, 2011


Key words Carcinoma, Acinar Cell; Pancreatic Neoplasms; S 1 (combination); Peritoneal Neoplasms; titanium silicide


Conflict of interest The authors have no potential conflict of interest


Hiroki Ohzato
Department of Surgery
Sakai Municipal Hospital
1-1-1, Minamiyasui-cho, Sakai-ku
Sakai, Osaka 590-0064
Phone: +81-72.221.1700
Fax: +81-72.225.3303




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