Future Directions in Pancreatic Cancer Therapy

David Orchard-Webb

doi:10.6092/1590-8577/2991

David Orchard-Webb University of Leeds. Leeds, UK

DOI: https://doi.org/10.6092/1590-8577/2991

Keywords: Drug Therapy, Combination, Immunotherapy, Oncolytic Virotherapy, Pancreatic Neoplasms

Abstract

Pancreatic cancer is a major disease burden that is essentially incurable at present. However significant understanding of the molecular basis of pancreatic cancer has been achieved through sequencing. This is allowing the rational design of therapeutics. The purpose of this review is to introduce the molecular basis of pancreatic cancer, explain the current state of molecular therapy and provide examples of the ongoing developments. These include improvements in chemotherapy, small molecule inhibitors, vaccines, immune checkpoint antibodies, and oncolytics.

Image: University of Leeds. Leeds, UK.

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