Small Cell Carcinoma of the Lung Presented as Acute Pancreatitis. Case Report and Review of the Literature
Abstract
Context Small cell carcinoma of the lung is an aggressive cancer with gloomy prognosis. Links to acute pancreatitis is extremely rare. Case report We are reporting a 53-year-old patient who was admitted because of acute pancreatitis. She had no history of gallstones, alcohol abuse, medications or any other predisposition for acute pancreatitis. Further investigations of blood, CT of chest abdomen and neck and ultrasound scan of abdomen, bone marrow and neck lymph node biopsies confirmed advanced small cell carcinoma of the lung with hypercalcemia, which was the only definite cause of acute pancreatitis. The patient made good recovery from pancreatitis after controlling the hypercalcemia. She was referred to respiratory team for further management of lung cancer. Conclusion Acute pancreatitis due to hypercalcemia of advanced small cell carcinoma of the lung is an extremely rare condition. Acute pancreatitis due to hypercalcemia should be thoroughly investigated to exclude serious pathology as in our case.
Image: Chest X-ray showing mediastinal mass.
Downloads
References
Belhassen-García M, Velasco-Tirado V, Carpio-Pérez A, Soler-Fernández MC, López-Bernús A, Pardo-Lledias J, Fuentes-Pardo L, Iglesias-Gómez A. Acute pancreatitis and obstructive jaundice secondary to metastases from lung cancer].Gastroenterol Hepatol. 2009 ;32:697-701.
Addeo A, Rinaldi C, Panades M. A case of small cell carcinoma of the prostate and review of the literature.Tumori. 2012;98:76e-8e
Tanaka H, Nakazawa T, Yoshida M, Miyabe K, Okumura F, Naitoh I, Hayashi K, Ando T, Ohara H, Joh T.Metastasis-induced acute pancreatitis in a patient with small cell carcinoma of the lungs.JOP. 2009;4;10:557-61
Kanno K, Hikichi T, Saito K, Watanabe K, Takagi T, Shibukawa G, Wakatsuki T, Imamura H, Takahashi Y, Sato A, Sato M, Irisawa A, Obara K, Ohira H. A case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis.Fukushima J Med Sci. 2007 ;53:51-60.
Bourgain A, Acker O, Lambaudie E, Boukerrou M, Chevalier-Place A, Meignie P, Parent M, Baranzelli MC, Cabaret V, Wemeau JL, Querleu D.[Small cell carcinoma of the ovary of the hypercalcemic type revealed by a severe acute pancreatitis: about one case].Gynecol Obstet Fertil. 2005 ;33:35-8.
Wynn D, Everett GD, Boothby RA.Small cell carcinoma of the ovary with hypercalcemia causes severe pancreatitis and altered mental status. Gynecol Oncol. 2004; 95:716-8.
Wymenga AN, van der Werf TS, van der Graaf WT, Tulleken JE, Zijlstra JG, Ligtenberg JJ.Lessons from an unusual case: malignancy associated hypercalcemia, pancreatitis and respiratory failure due to ARDS.Neth J Med. 1999; 54:27-30.
Hsieh TL, Chen JJ, Chien CS, Chiou SS, Tai DI, Lee CN, Kuo CH, Chiu KW, Chuah SK, Hu TH.[Small cell lung cancer with liver and bone metastasis associated with hypercalcemia and acute pancreatitis--a case report].Changgeng Yi Xue Za Zhi. 1995; 18:190-3.
Tan J,Calvo A.Small cell carcinoma presenting as acute pancreatitis :the role of hypercalcemia. World J Oncol . 2012;3:42-44
Frick TW, Mithöfer K, Fernández-del Castillo C, Rattner DW, Warshaw AL.Hypercalcemia causes acute pancreatitis by pancreatic secretory block, intracellular zymogen accumulation, and acinar cell injury.Am J Surg. 1995 ; 169: 167-72.
Stewart KC, Dickout WJ, Urschel JD.Metastasis-induced acute pancreatitis as the initial manifestation of bronchogenic carcinoma.1993;104:98-100.
Kim KH, Kim CD, Lee SJ, Lee G, Jeen YT, Lee HS, Chun HJ, Song CW, Um SH, Lee SW, Choi JH, Ryu HS, Hyun JH. Metastasis-induced acute pancreatitis in a patient with small cell carcinoma of the lung.J Korean Med Sci. 1999 ;14:107-9.
Huang YW, Yang JC, Chang YL, Tsang YM, Wang TH.Acute pancreatitis combined with acute Budd-Chiari syndrome as the initial manifestation of small cell lung cancer.J Formos Med Assoc. 2005 ;104:431-5.
Woo JS, Joo KR, Woo YS, Jang JY, Chang YW, Lee J 2nd, Chang R.Pancreatitis from metastatic small cell lung cancer successful treatment with endoscopic intrapancreatic stenting.Korean J Intern Med. 2006; 21:256-61.
Belhassen-García M, Velasco-Tirado V, Carpio-Pérez A, Soler-Fernández MC, López-Bernús A, Pardo-Lledias J, Fuentes-Pardo L, Iglesias-Gómez A.Acute pancreatitis and obstructive jaundice secondary to metastases from lung cancer. Gastroenterol Hepatol. 2009 ;32:697-701.
Tanaka H, Nakazawa T, Yoshida M, Miyabe K, Okumura F, Naitoh I, Hayashi K, Ando T, Ohara H, Joh T.Metastasis-induced acute pancreatitis in a patient with small cell carcinoma of the lungs.JOP. 2009 ;10:557-61.
Wurm Johansson G, Toth E, Torp J, Ehinger A, Anderson L, Thorlacius H.Acute pancreatitis evoked by small-cell lung carcinoma metastases and detected by endoscopic ultrasound. Endoscopy. 2012;44:E45-6.
Copyright (c) 2014 Abdulzahra Hussain, Ali Adnan, Shamsi EL-Hasani
This work is licensed under a Creative Commons Attribution 4.0 International License.
As a member of Publisher International Linking Association, PILA, iMedPub Group’s JOP follows the Creative Commons Attribution License and Scholars Open Access publishing policies. Journal of the Pancreas is the Council Contributor Member of Council of Science Editors (CSE) and following the CSE slogan Education, Ethics, and Evidence for Editors.