Acute Necrotizing Pancreatitis in the Setting of CMV Viremia and AIDS: A Case Report and Review of Literature from 1980 to 2012

  • Stephen Osiro Department of Medicine, Woodhull Medical Center. Brooklyn, NY, USA
  • Raza Muhammad Department of Medicine, Woodhull Medical Center. Brooklyn, NY, USA
  • Jose Ruiz Department of Pathology, Woodhull Medical Center. Brooklyn, NY, USA
  • Anatole Sladen Department of Radiology, Woodhull Medical Center. Brooklyn, NY, USA
  • Njambi Mathenge St. George’s University School of Medicine. Grenada, West Indies
  • Kevin J Tiwari St. George’s University School of Medicine. Grenada, West Indies
Keywords: Acquired Immunodeficiency Syndrome, Cytomegalovirus, Ganciclovir, Necrosis, Pancreatitis


Context Cytomegalovirus (CMV)-induced pancreatitis in patients with AIDS is a known entity with poor prognosis. Case report We report a case of a 43-year-old woman with AIDS and CMV viremia who was evaluated for hypotension and found to have severe necrotizing pancreatitis. The authors have also conducted a MEDLINE search for CMV-induced pancreatitis from 1980 to 2012 and reviewed the pertinent results. Discussion Until mid-1990s in the United States, pancreatitis due to CMV was mainly diagnosed at autopsy in AIDS patients. However, presumably due to the advent of antiretroviral therapy, there has since been a significant decline in the number of reported cases among these individuals. Rather, our review revealed that the occurrence of CMV-induced pancreatitis has since been described in a variety of clinical settings, ranging from patients on corticosteroid therapy to immunocompetent persons. Conclusions Clinicians need a high index of suspicion to timely diagnose CMV-induced pancreatitis as patients often present with non-specific signs and symptoms. As it occurred in our case, early intervention is crucial and may alter the outcome in such patients.

Image: Immunohistochemistry study showing human herpes virus type 8 (HHV-8).


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Immunohistochemistry study showing human herpes virus type 8 (HHV-8)
How to Cite
OsiroS., MuhammadR., RuizJ., SladenA., MathengeN., & TiwariK. (2012). Acute Necrotizing Pancreatitis in the Setting of CMV Viremia and AIDS: A Case Report and Review of Literature from 1980 to 2012. JOP. Journal of the Pancreas, 13(6), 705-711.