A Fast Track Recovery Program Significantly Reduces Hospital Length of Stay Following Uncomplicated Pancreaticoduodenectomy

  • Mehrdad Nikfarjam Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Laurence Weinberg Department of Anaesthesia, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Nicholas Low Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Michael A Fink Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Vijayaragavan Muralidharan Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Nezor Houli Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Graham Starkey Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Robert Jones Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
  • Christopher Christophi Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
Keywords: Length of Stay, Outcome Assessment (Health Care), Pancreatectomy, Patient Readmission, Postoperative Complications

Abstract

Context Factors affecting length of hospital stay after uncomplicated pancreaticoduodenectomy have not been reported. We hypothesized that patients undergoing uncomplicated pancreaticoduodenectomy treated by fast track recovery program would have a shorter length of hospital stay compared to those managed by a standard program. Methods Patients without surgical or medical complications following pancreaticoduodenectomy managed by fast track or standard protocols, between 2005 and 2011, were identified and prognostic predictors for length of hospital stay determined. Results Forty-one patients treated by pancreaticoduodenectomy had no medical or surgical complications during this period. Of these patients, 20 underwent fast track recovery program compared to 21 who underwent standard care. Patients in the standard group were more likely to have a feeding jejunostomy tube (P<0.001), pylorus preserving procedure (P=0.001) and a nasogastric tube in place longer than 24 hours postoperatively (P<0.001). The median postoperative length of stay was shorter in the fast track recovery program group (8 days, range: 7-16 days) versus 14 days, range: 8-29 days; P<0.001). There were three readmissions in the fast track recovery program related to abdominal pain and none in the standard group. The overall length of stay, accounting for readmissions, still remained significantly shorter in the fast track recovery program group (median 9 days, range: 7-17 days versus median14 days, range: 8-29 days ; P<0.001). There were no significant differences in discharge destination between groups. On multivariate analysis, the only factor independently associated with postoperative discharge by day 8 was fast track recovery program (OR: 37.1, 95% CI: 4.08-338; P<0.001). Conclusion Fast track recovery program achieved significantly shorter length of stay following uncomplicated pancreaticoduodenectomy.

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Author Biography

Mehrdad Nikfarjam, Department of Surgery, University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
Senior Lecturer, Univeristy Department of Surgey

References

Basse L, Thorbol JE, Lossl K, Kehlet H. Colonic surgery with accelerated rehabilitation or conventional care. Dis Colon Rectum. 2004;47(3):271-7; discussion 7-8. Epub 2004/03/03.

Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg. 2002;183(6):630-41. Epub 2002/07/04.

Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008;248(2):189-98. Epub 2008/07/25.

Wind J, Polle SW, Fung Kon Jin PH, Dejong CH, von Meyenfeldt MF, Ubbink DT, et al. Systematic review of enhanced recovery programmes in colonic surgery. Br J Surg. 2006;93(7):800-9. Epub 2006/06/16.

Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA. A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg. 2007;245(6):867-72. Epub 2007/05/25.

Kehlet H. Fast-track colorectal surgery. Lancet. 2008;371(9615):791-3. Epub 2008/03/11.

Wichmann MW, Roth M, Jauch KW, Bruns CJ. A prospective clinical feasibility study for multimodal “fast track” rehabilitation in elective pancreatic cancer surgery. Rozhl Chir. 2006;85(4):169-75. Epub 2006/05/25.

Berberat PO, Ingold H, Gulbinas A, Kleeff J, Muller MW, Gutt C, et al. Fast track--different implications in pancreatic surgery. J Gastrointest Surg. 2007;11(7):880-7. Epub 2007/04/19.

French JJ, Mansfield SD, Jaques K, Jaques BC, Manas DM, Charnley RM. Fast-track management of patients undergoing proximal pancreatic resection. Ann R Coll Surg Engl. 2009;91(3):201-4. Epub 2009/02/18.

di Sebastiano P, Festa L, De Bonis A, Ciuffreda A, Valvano MR, Andriulli A, et al. A modified fast-track program for pancreatic surgery: a prospective single-center experience. Langenbecks Arch Surg. 2011;396(3):345-51. Epub 2010/08/13.

Kennedy EP, Rosato EL, Sauter PK, Rosenberg LM, Doria C, Marino IR, et al. Initiation of a critical pathway for pancreaticoduodenectomy at an academic institution--the first step in multidisciplinary team building. J Am Coll Surg. 2007;204(5):917-23; discussion 23-4. Epub 2007/05/08.

Tan WJ, Kow AW, Liau KH. Moving towards the New International Study Group for Pancreatic Surgery (ISGPS) definitions in pancreaticoduodenectomy: a comparison between the old and new. HPB (Oxford). 2011;13(8):566-72. Epub 2011/07/19.

Pratt WB, Maithel SK, Vanounou T, Huang ZS, Callery MP, Vollmer CM, Jr. Clinical and economic validation of the International Study Group of Pancreatic Fistula (ISGPF) classification scheme. Ann Surg. 2007;245(3):443-51. Epub 2007/04/17.

Wente MN, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, Izbicki JR, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142(5):761-8.

Nikfarjam M, Kimchi ET, Gusani NJ, Shah SM, Sehmbey M, Shereef S, et al. A reduction in delayed gastric emptying by classic pancreaticoduodenectomy with an antecolic gastrojejunal anastomosis and a retrogastric omental patch. J Gastrointest Surg. 2009;13(9):1674-82. Epub 2009/06/24.

Yang D, He W, Zhang S, Chen H, Zhang C, He Y. Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial. World J Surg. 2012. Epub 2012/04/25.

Balzano G, Zerbi A, Braga M, Rocchetti S, Beneduce AA, Di Carlo V. Fast-track recovery programme after pancreatico- duodenectomy reduces delayed gastric emptying. Br J Surg. 2008;95(11):1387-93. Epub 2008/10/11.

Ypsilantis E, Praseedom RK. Current status of fast-track recovery pathways in pancreatic surgery. JOP. 2009;10(6):646-50. Epub 2009/11/06.

Mukherjee S, Kocher HM, Hutchins RR, Bhattacharya S, Abraham AT. Impact of hospital volume on outcomes for pancreaticoduodenectomy: a single UK HPB centre experience. Eur J Surg Oncol. 2009;35(7):734-8. Epub 2008/06/13.

Balzano G, Zerbi A, Capretti G, Rocchetti S, Capitanio V, Di Carlo V. Effect of hospital volume on outcome of pancreaticoduodenectomy in Italy. Br J Surg. 2008;95(3):357-62. Epub 2007/10/13.

Kennedy EP, Grenda TR, Sauter PK, Rosato EL, Chojnacki KA, Rosato FE, Jr., et al. Implementation of a critical pathway for distal pancreatectomy at an academic institution. J Gastrointest Surg. 2009;13(5):938-44. Epub 2009/02/05.

Carli F, Charlebois P, Baldini G, Cachero O, Stein B. An integrated multidisciplinary approach to implementation of a fast-track program for laparoscopic colorectal surgery. Can J Anaesth. 2009;56(11):837-42. Epub 2009/07/30.

Sjostedt L, Hellstrom R, Stomberg MW. Patients' need for information prior to colonic surgery. Gastroenterol Nurs. 2011;34(5):390-7. Epub 2011/10/08.

Harper CM, Lyles YM. Physiology and complications of bed rest. J Am Geriatr Soc. 1988;36(11):1047-54. Epub 1988/11/01.

Nelson R, Edwards S, Tse B. Prophylactic nasogastric decompression after abdominal surgery. Cochrane Database Syst Rev. 2007(3):CD004929. Epub 2007/07/20.

Cheatham ML, Chapman WC, Key SP, Sawyers JL. A meta-analysis of selective versus routine nasogastric decompression after elective laparotomy. Ann Surg. 1995;221(5):469-76; discussion 76-8. Epub 1995/05/01.

Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg. 1997;226(5):632-41. Epub 1997/12/06.

Grocott MP, Mythen MG, Gan TJ. Perioperative fluid management and clinical outcomes in adults. Anesth Analg. 2005;100(4):1093-106. Epub 2005/03/23.

Schnuriger B, Inaba K, Wu T, Eberle BM, Belzberg H, Demetriades D. Crystalloids after primary colon resection and anastomosis at initial trauma laparotomy: excessive volumes are associated with anastomotic leakage. J Trauma.70(3):603-10. Epub 2011/05/26.

University of Melbourne, Austin Health. Heidelberg, Victoria, Australia
Published
2013-01-10
How to Cite
NikfarjamM., WeinbergL., LowN., FinkM., MuralidharanV., HouliN., StarkeyG., JonesR., & ChristophiC. (2013). A Fast Track Recovery Program Significantly Reduces Hospital Length of Stay Following Uncomplicated Pancreaticoduodenectomy. JOP. Journal of the Pancreas, 14(1), 63-70. https://doi.org/10.6092/1590-8577/1223
Section
ORIGINAL ARTICLES

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