Prognostic and Predictive Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors

  • Ryan Stevenson Tufts University School of Medicine. Boston, MA, USA
  • Steven k Libutti Albert Einstein College of Medicine. Bronx, NY, USA
  • Muhammad Wasif Saif Tufts University School of Medicine. Boston, MA, USA
Keywords: Biological Markers, Gastro-enteropancreatic Neuroendocrine tumors, PHLPP2 protein, human, Succinate Dehydrogenase

Abstract

Neuroendocrine tumors (NET) are a diverse group of tumors that derive from epithelial cells with neuroendocrine differentiation. Gastroenteropancreatic NETs are a subset of NET that arise from the gastrointestinal tract. The natural history and prognosis varies widely between different gastroenteropancreatic NETs, highlighting the importance of identifying accurate prognostic and predictive biomarkers. At the 2013 ASCO Gastrointestinal Cancers Symposium, De Braud et al. (Abstract #186) and Bellister et al. (Abstract #163) present data on two new possible biomarkers.

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Author Biographies

Ryan Stevenson, Tufts University School of Medicine. Boston, MA, USA

Tufts Medical Center

Fellow, Division of Hematology/Oncology

Steven k Libutti, Albert Einstein College of Medicine. Bronx, NY, USA

Director, Montefiore-Einstein Center for Cancer Care

Associate Director for Clinical Services, Albert Einstein Cancer Center
The Marvin L. Gliedman, M.D. Distinguished Surgeon
Professor and Vice-Chairman, Department of Surgery
Professor, Department of Genetics
Montefiore Medical Center/Albert Einstein College of Medicine
Muhammad Wasif Saif, Tufts University School of Medicine. Boston, MA, USA

Assistant Professor, Tufts University School of Medicine

Director, GI Oncology Program

Leader, Experimental Therapeutics

References

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Ter-Minassian, Monica et al. "Prospective analysis of clinical outcomes and prognostic factors in patients with neuroendocrine tumors (NETs)." J Clin Oncol (Meeting Abstracts) May. 2010: 4044.

Arnold, Rudolf et al. "Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors." Clinical Gastroenterology and Hepatology 6.7 (2008): 820-827. PMID: 18547872

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Yao JC et al. “Multivariate analysis including biomarkers in the phase III RADIANT-2 study of octreotide LAR plus everolimus (E+O) or placebo (P+O) among patients with advanced neuroendocrine tumors (NET).” J Clin Oncol 30, 2012 (suppl; abstr 4014).

De Braud et al. “Loss of succinate dehydrogenase (SDHB) in midgut carcinoids as a prognostic factor: A new marker of personalized cancer medicine in neuroendocrine tumors?” J Clin Oncol 30: 2012 (suppl 34; abstr 186)

Barletta, Justine A, and Jason L Hornick. "Succinate Dehydrogenase-deficient Tumors: Diagnostic Advances and Clinical Implications." Advances in Anatomic Pathology 19.4 (2012): 193-203. PMID 22692282

Bellister et al. “Prediction of prognosis in patients treated with everolimus for extrapancreatic neuroendocrine tumors by a single nucleotide polymorphism in PHLPP2.” J Clin Oncol 30: 2012 (suppl 34; abstr 163)

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O’Neill AK, Newton AC. PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2). Atlas Genet Cytogenet Oncol Haemotol. June 2009.

Logo (Tufts Medical Center. Boston, MA, USA)
Published
2013-03-10
How to Cite
Stevenson, R., Libutti, S., & Saif, M. (2013). Prognostic and Predictive Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors. JOP. Journal of the Pancreas, 14(2), 155-157. https://doi.org/10.6092/1590-8577/1472
Section
Highlights from the “2013 ASCO Gastrointestinal Cancers Symposium”. San Francisco, CA, USA. January 24-26, 2013

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