Hepatoid Variant of Pancreatic Cancer: Insights from a Case and Literature Review

  • Shounak Majumder Department of Internal Medicine, University of Connecticut. Farmington, CT, USA
  • Constantin A Dasanu Department of Hematology-Oncology, Saint Francis Medical Center. Hartford, CT, USA
Keywords: alpha-Fetoproteins, Carcinoma, Hepatocellular, Pancreatic Neoplasms


Context “Hepatoid” cancer refers to an extrahepatic neoplasm with hepatocellular differentiation. The stomach is the most common site and pancreatic origin is distinctly uncommon. Case report We describe a patient with hepatoid pancreatic tumor who presented with inoperable metastatic disease. Conclusion Serum levels or tissue staining with alpha-fetoprotein (AFP) may not be a reliable tumor marker in these cases and an experienced pathologist and appropriate immunohistochemical staining are essential for early diagnosis. This report incorporates a comprehensive literature review outlining the clinical presentation, diagnostic difficulties, management and outcomes associated with this rare pathological entity.

Image: Liver biopsy.


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Liver biopsy
How to Cite
MajumderS., & DasanuC. (2013). Hepatoid Variant of Pancreatic Cancer: Insights from a Case and Literature Review. JOP. Journal of the Pancreas, 14(4), 442-445. https://doi.org/10.6092/1590-8577/1476