A First Report of Endoscopic Ultrasound for the Diagnosis of Pancreatic Amyloid Deposition in Immunoglobulin Light Chain (AL) Amyloidosis (Primary Amyloidosis)

  • Somashekar G Krishna Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA
  • Manoop S Bhutani Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA
  • Charles H Mosher Department of Pathology, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA
  • Gregg A Staerkel Department of Pathology, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA
  • Brian R Weston Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA
DOI: https://doi.org/10.6092/1590-8577/1505
Keywords: Amyloidosis, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Pancreas

Abstract

Context Pancreatic involvement in systemic light chain (AL)-amyloidosis is exceedingly rare. Prior reports of endoscopic ultrasound (EUS) for the diagnosis of amyloidosis are also limited. Case report We report the first description of EUS-guided fine needle aspiration (FNA) for the diagnosis of primary AL-amyloidosis involving the pancreas. Conclusion: EUS-FNA can be effectively utilized for the characterization and cytologic diagnosis of pancreatic amyloidosis and potentially other accessible extraluminal amyloid deposits.

Image: Abundant amorphous acellular waxy appearing proteinaceous deposits.

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Author Biographies

Somashekar G Krishna, Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA

Dr. Krishna was Gastroenterology - Therapeutic Endoscopy Fellow  (completed June 2012)

Department Gastroenterology, Hepatology and Nutrition

The University of Texas MD Anderson Cancer Center

Manoop S Bhutani, Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA

Professor of Medicine

Department Gastroenterology, Hepatology and Nutrition

The University of Texas MD Anderson Cancer Center

Charles H Mosher, Department of Pathology, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA

Dr. Mosher was a Pathology Fellow  (completed June 2012)

Department Pathology

The University of Texas MD Anderson Cancer Center

Gregg A Staerkel, Department of Pathology, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA

Professor of Medicine

Department Pathology

The University of Texas MD Anderson Cancer Center

Brian R Weston, Department of Gastroenterology, Hepatology and Nutrition, The University of Texas M. D. Anderson Cancer Center. Houston, TX, USA

Assistant Professor of Medicine

Department Gastroenterology, Hepatology and Nutrition

The University of Texas MD Anderson Cancer Center

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Abundant amorphous acellular waxy appearing proteinaceous deposits
Published
2013-05-10
How to Cite
KrishnaS., BhutaniM., MosherC., StaerkelG., & WestonB. (2013). A First Report of Endoscopic Ultrasound for the Diagnosis of Pancreatic Amyloid Deposition in Immunoglobulin Light Chain (AL) Amyloidosis (Primary Amyloidosis). JOP. Journal of the Pancreas, 14(3), 283-285. https://doi.org/10.6092/1590-8577/1505
Issue
Vol 14 No 3 (2013): May - p. 221-303
Section
CASE REPORTS

Copyright (c) 2014 Somashekar G Krishna, Manoop S Bhutani, Charles H Mosher, Gregg A Staerkel, Brian R Weston

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