Micronutrient Therapy for Chronic Pancreatitis: Premises and Pitfalls

  • Joan Marie Braganza Department of Medicine, University of Manchester. Manchester, United Kingdom
Keywords: Antioxidants, Mast Cells, Nociceptors

Abstract

No abstract available.

Image: The first home of the Medical School of University of Manchester, United Kingdom (as seen in 1908).

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Author Biography

Joan Marie Braganza, Department of Medicine, University of Manchester. Manchester, United Kingdom

Emeritus Reader

honorary Consultant Gastroenterologist

References

Siriwardena AK, Mason J, Sheen AJ, Makin AJ, Shah NS. Antioxidant therapy does not reduce pain in patients with chronic pancreatitis: The Anticipate study. Gastroenterology 2012; 143: 655-63.

Pezzilli R. Antioxidants for intractable pain in chronic pancreatitis patients. Is the end of the story? J Pancreas (on-line) 2012; 13: 461-3.

Forsmark CE, Liddle RA. The challenging task of treating painful chronic pancreatitis. Gastroenterology 2012; 143: 533-5.

Letters to the Editor from Braganza JM, Taludkar R and Reddy DN, Mantle D, Garg PK. Gastroenterology 2013; 144: e17-20.

Siriwardena AK, Mason J. Reply. Gastroenterology 2013; 144: e20-1.

Braganza JM, Lee SH, McCloy RF, McMahon MJ. Chronic pancreatitis. Lancet 2011; 377: 1184-97.

Liu L, Shenoy M, Pasricha PJ. Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor. J Pancreas (On-line) 2011; 12: 389-94.

Zhu Y, Colak T, Shenoy M, Liu L, Mehta K, Pai R, et al. Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Molecular pain 2012; 8: 65 [ doi 10.1186/1744-8069-8-65]

Zhu Y, Colak T, Shenoy M, Liu L, Pai R, Li C, et al. Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis. Gastroenterology 2011; 141:370-7.

Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokushi A, Kohsaka S, Salter MW, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 2003; 424: 778-83.

Braganza JM, Dormandy TL. Micronutrient therapy for chronic pancreatitis: rationale and impact. J Pancreas (on-line) 2010; 11: 99-112.

Gaiser S, Daniluk J, Liu Y, Tsou L, Chu J, Lee W, et al. Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. Gut 2011; 60: 1379-88.

Braganza JM. Towards a novel treatment strategy for acute pancreatitis 1. Reappraisal of the evidence on aetiogenesis. Digestion 2001; 63: 69-91.

Segal I, Chaloner C, Douglas J, John K-D, Zaidi A, Cotter L, et al. Acute pancreatitis in Soweto, south Africa: relationship between trypsinogen load, trypsinogen activation, and fibrinolysis. Am J Gastreoenterol 2002; 97: 883-92.

Tandon RH, Garg PK. Oxidative stress in chronic pancreatitis: pathophysiological relevance and management. Antioxid Redox Signal 2011; 15: 2757-66.

Segal I, Ally R, Hunt LP, Sandle LN, Ubbink JB, Braganza JM. Insights into the development of alcoholic chronic pancreatitis at Soweto, south Africa. Pancreas 2011; 40: 508-16.

Namazi MR. Hypothesis. Cytochrome-P450 enzymes and autoimmunity: expansion of the relationship and introduction of free radicals as the link. Journal of Autoimmune Disease 2009; 6:4 (doi: 10.1186/1740-2557-6-4).

Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, et al. Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci USA 1994; 91: 3739-43.

Valdovinos-Flores C, Gonsebatt ME. Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by butathionine sulfoxime, arsenic, and acetaminophen. Free Radical Research 2013; 47: 404-12. [ISSN 1071-5762]

Stander S, Moormann C, Schmuchar M, Buddenkotte J, Artuc M, Shpacovitch V, et al. Expression of vallinoid receptor subtype 1 in cutaneous sensory nerve fibres, mast cells, and epithelial cells of appendage structures. Experimental Dermatology 2004; 13: 129-39.

Zhang D, Spielmann A, Wang L, Ding G, Huang F, Gu Q, et al. Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2. Physiol Res 2012; 61: 113-24.

Braganza JM. A framework for the aetiogenesis of chronic pancreatitis. Digestion 1998; 59 suppl 4: 1-12.

Yuan H, Zhu X, Zhou S, Chen Q, Zhu X, Ma X, et al. Role of mast cell activation in inducing microglial cells to release neurotrophin. Journal of Neuroscience Research 2010; 83: 1348-54.

Lindstedt KA, Wang Y, Shiota N, Saarinen J, Hyytianen M, Kokkonen Jo, et al. Activation of paracrine TGF-ß1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. FASEB J 2001; 15: 1377-88.

Horigome K, Pryor JC, Bullock ED, Johnson EM. Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation. J Biol Chem 1993; 268: 14881-7.

Dirckx M, Groenweg PT, van Daele PLA, Stronks DL, Huygen FJPM. Mast cells: a new target in the treatment of complex regional pain syndrome? Pain Practice 2013; DOI.10.1111/papr.12049

Durgaprasad S, Pai CG, Vasanthkumar, Alvres JF, Namitha SA. A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian J Med Res 2005;122:315-8. [ PMID 16394323].

Choi Y-H, Yan G-H, Chai OH, Song CH. Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation. Anat Cell Biol 2010; 43: 36-43.

Braganza JM. Mast cell control: likely modus operandi of panhaematin in experimental pancreatitis. Gut 2012; 61: 632. [doi: 10.1136/gutjnl-2011.300415]

Braganza JM. Towards a novel treatment strategy for acute pancreatitis. 2. Principles and potential practice. Digestion 2001; 63: 143-62.

Padmalatha K, Reddy GN, Narayana TV, Satyanarayana S. In vitro protection of rat mesenteric mast cells from C 48/80 by selected antioxidant herbal extracts (aqueous) and antioxidant substances. Pharmanest 2010; 1: 205-12. [Issn no. 0976-3090]

Yang L-Y, Ko W-C, Lin C-M, Lin J-W, Wu J-C, Lin C-J, et al. Antioxidant N-acetylcysteine blocks nerve growth factor-induced H2O2/ERK signaling in PC12 cells. Ann NY Acad Sci 2005; 1042:325-37.[doi:10.1196/annals.1338.056]

Ditĕ P, Prĕcechtelová M, Novotný I, Soška V, ŹákováA, Lata J. Changes of reactive oxidative substances in patients with morphologically different degrees of chronic pancreatitis and effects of long-term therapy with natural antioxidants. Gastroenterologia Polska 2003; 10: 379-83.

Herrick AL, Hollis S, Schofield D, Rieley F, Blann A, Griffin K, et al. A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis. Clinical and Experimental Rheumatology 2000; 18: 349-56.

Uden S, Schofield D, Miller PF, Day JP, Bottiglieri T, Braganza JM. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. Aliment Pharmacol Ther 1992; 6: 229-40.

Dhingra R, Singh N, Sachdev V, Upadhaya AD, Saraya A. Effect of antioxidant supplementation on surrogate markers of fibrosis in chronic pancreatitis. A randomized placebo-controlled trial. Pancreas 2013; on-line ahead of journal publication.

Chauhan SS, Pannu DS, Forsmark CE. Antioxidants as adjuvant therapy for pain in chronic pancreatitis. Practical Gastroenteroloigy 2012: Nutrition issues in Gastroenterology, series #103.

Grigsby B, Rodriguez-Rilo H, Khan K. Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy. Dig Dis Sci 2012; 57: 835-41.

Shah NS, Makin AJ, Sheen AJ, Siriwardena AK. Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy. WJG 2010; 16: 4066-71.

Bhardwaj P, Garg PK, Maulik SK, Saraya A, Tandon RK, Acharya SK. A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology 2009; 136: 149-59.

Palmieri B, Sblendorio V. Oxidative stress tests: overview on reliability and use. European Review for Medical and Pharmacological Sciences. 2007; 11: 308-42.

Winterbourn CC, Bonham MJ, Buss H, Abu-Zidan FM, Windsor JA. Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis. Pancreatology 2003; 3: 375-82.

Schofield D, Braganza JM. Shortcomings of an automated assay for total antioxidant status in biological fluids. Clin Chem 1996; 42: 1712-4.

Girish BN, Vaidyanathan K, Rao NA, Rajesh G, Balakrishnan V. Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways. Pancreas 2010; 39: e11-16. (PMID 20050230)

Syrota A, Dop-Ngassa M, Paraf A. 11C-L-methionine for evaluation of pancreatic exocrine function. Gut 1981; 22:907-15.

Wehler M, Nichterlein R, Fischer B, Farnbacher M, Reulbach U, Hahn EG, et al. Factors associated with health-related quality of life in chronic pancreatitis. Am J Gastroenterol 2004; 99: 138-46.

Dumsay V, Delhaye M, Cotoon F, Deviere J. Fat malabsorption screening in chronic pancreatitis. Am J Gastroenterol 2004; 99: 1350-4.

Ammann RW. Diagnosis and management of chronic pancreatitis: current knowledge. Swiss Med Wkly 2006; 136: 166-74.

McCloy RF. Chronic pancreatitis at Manchester, UK. Focus on antioxidant therapy. Digestion 1998; 59 suppl 4: 36-48.

The first home of the Medical School of University of Manchester, United Kingdom (as seen in 1908)
Published
2013-07-10
How to Cite
BraganzaJ. (2013). Micronutrient Therapy for Chronic Pancreatitis: Premises and Pitfalls. JOP. Journal of the Pancreas, 14(4), 304-308. https://doi.org/10.6092/1590-8577/1580