Pancreatic Glucagonoma Metastasising to the Right Ovary Five Years after Initial Surgery: A Case Report
Abstract
Context Glucagonomas of the pancreas are neuroendocrine tumours (NETs) that arise from well-differentiated neuroendocrine cells within the pancreatic islets. They are considered to be aggressive NETs and often have metastases at initial presentation. In contrast localised glucagonoma without metastatic spread may have prolonged disease free survival with radical resectional surgery. Case report The authors present a case of a glucagonoma that initially presented with classical necrolytic migratory erythema and a large solitary mass in the body and tail of the pancreas that was surgically resected. Five years after surgery the patient presented with increased serum glucagon levels and a mass in the right ovary. Pathology of the resected ovary after oophorectomy identified this as an isolated metastatic glucagonoma. Conclusion Glucagonoma is a rare pancreatic NET that has significant malignant potential. This is the first case of a pancreatic glucagonoma metastasising to the ovary 5 years after radical distal pancreatosplenectomy.
Image: Dermatosis affecting the axilla.
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References
Oberg K. Pancreatic endocrine tumors. Semin Oncol 2010; 37:594-618. [PMID: 21167379]
Fernández-Cruz L, Blanco L, Cosa R, Rendón H. Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumors? World J Surg 2008; 32:904-17. [PMID: 18264824]
Chastain MA. The glucagonoma syndrome: a review of its features and discussion of new perspectives. Am J Med Sci 2001; 321:306-20. [PMID: 11370794]
Dinc B, Sahin C. Metastatic glucagonoma. Eurasian Journal of Medicine 2009; 41:70-2.
Akerström G, Hellman P, Hessman O, Osmak L. Surgical treatment of endocrine pancreatic tumours. Neuroendocrinology 2004; 80:62-6. [PMID: 15477720]
Beattie PE, Fleming CJ, Evans AT, Sheppard DG, Leese GP, Dow E, Tait IS. Glucagonoma syndrome presenting as psoriasis. QJM 2002; 95:34-5. [PMID: 12454329]
Song KB, Kim SC, Park JB, Kim YH, Jung YS, Kim MH, et al. Single-center experience of laparoscopic left pancreatic resection in 359 consecutive patients: changing the surgical paradigm of left pancreatic resection. Surg Endosc 2011; 25:3364-72. [PMID: 21556993]
Nakamura M, Kakashima H. Laparoscopic distal pancreatectomy and pancreatoduodenectomy: is it worthwhile? A meta-analysis of laparoscopic pancreatectomy. J Hepatobiliary Pancreat Sci 2013; 4:421-8. [PMID: 23224732]
Rosok BI, Marangos IP, Kazaryan AM et al. Single-centre experience of laparoscopic pancreatic surgery. Br J Surg 2010; 97:902-9. [PMID: 20474000]
Jusoh AC, Ammori BJ. Laparoscopic versus open distal pancreatectomy: a systematic review of comparative studies. Surg Endosc 2012; 26:904-13. [PMID: 22083328]
Venkat R, Edil BH, Schulick RD, Lidor AO, Makary MA, Wolfgang CL. Laproscopic distal pancreatectomy is associated with significantly less overall morbidity compared to the open technique: A systematic review and meta-analysis. Ann Surg 2012; 255:1048-59. [PMID: 22511003]
Willis RA. The Spread of Tumours in the Human Body. 3rd edition. London, England: Churchill Publishers 1934:312-7. [ISBN: 9780407399013]
Hibner M, Greenspan D. Ovarian metastases from the biliary tract, pancreas and liver carcinomas. CME Journal of Gynaecologic Oncology 2004; 9:5-128.
Copyright (c) 2014 David Graham Watt, Sanjay Pandanaboyana, Charles Simon Herrington, Iain S Tait
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