Pancreatic Somatostatinoma Diagnosed Preoperatively: Report of a Case

  • Yasuhisa Mori Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Norihiro Sato Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Ryuta Taniguchi Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Toshihisa Tamura Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Noritaka Minagawa Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Kazunori Shibao Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Aiichiro Higure Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Mitsuhiro Nakamoto Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Masashi Taguchi Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
  • Koji Yamaguchi Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan
DOI: https://doi.org/10.6092/1590-8577/1884
Keywords: Endoscopic Ultrasound-Guided Fine Needle Aspiration, Pancreatic Neoplasms, Somatostatin /blood, Somatostatinoma

Abstract

Context Somatostatinoma is a rare neoplasm of the pancreas. Preoperative diagnosis is often difficult. Case report We report a 72-year-old woman with a pancreatic head tumor measuring 37 mm in diameter, and enlargement of the lymph nodes on the anterior surface of the pancreatic head and the posterior surface of the horizontal part of the duodenum. Laboratory data showed an elevated plasma somatostatin concentration. Examination of a biopsy specimen of the pancreatic head mass obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) showed histopathological features of a neuroendocrine tumor. Immunohistochemical staining showed that the tumor cells were positive for somatostatin, leading to a preoperative diagnosis of pancreatic somatostatinoma. The patient underwent pylorus-preserving pancreaticoduodenectomy. The plasma somatostatin concentration decreased progressively after surgery. Conclusions A rare case of pancreatic somatostatinoma with lymph node metastases was presented. Immunohistochemical analysis of a biopsy specimen obtained by EUS-FNA was useful for preoperative diagnosis.

Image: Location of a pancreatic somatostatinoma and lymph node metastases.

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Location of a pancreatic somatostatinoma and lymph node metastases
Published
2014-01-10
How to Cite
MoriY., SatoN., TaniguchiR., TamuraT., MinagawaN., ShibaoK., HigureA., NakamotoM., TaguchiM., & YamaguchiK. (2014). Pancreatic Somatostatinoma Diagnosed Preoperatively: Report of a Case. JOP. Journal of the Pancreas, 15(1), 66-71. https://doi.org/10.6092/1590-8577/1884
Issue
Vol 15 No 1 (2014): January - p. 1-83
Section
CASE REPORTS

Copyright (c) 2014 Yasuhisa Mori, Norihiro Sato, Ryuta Taniguchi, Toshihisa Tamura, Noritaka Minagawa, Kazunori Shibao, Aiichiro Higure, Mitsuhiro Nakamoto, Masashi Taguchi, Koji Yamaguchi

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