Novel Agents for the Treatment of Pancreatic Cancer

  • Gregory T Brennan Department of Internal Medicine, University of Texas Southwestern Medical Center. Dallas, TX, USA
  • Valerie Relias Division of GI Oncology and Experimental Therapeutics, Tufts Medical Center. Boston, MA, USA
  • Muhammad Wasif Saif Division of GI Oncology and Experimental Therapeutics, Tufts Medical Center. Boston, MA, USA
Keywords: Antibodies, Monoclonal, Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Listeria monocytogenes, mesothelin, Pancreatic Neoplasms, STA 9090, Vaccines


Metastatic pancreatic cancer continues to be a difficult disease to treat because of its aggressive nature, advanced stage at presentation and lack of treatment options. There is a need for the development of new agents directed against novel targets to improve outcomes for these patients. At the 2014 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium phase I/II trials provided information on three novel strategies for treating metastatic pancreatic cancer. Immunotherapy in the form of a vaccine (GVAX) followed with an immune stimulator (CRS-207) showed extended survival (Abstract #177). A monoclonal antibody (NEO-102) targeting MUC5AC also showed activity and was well tolerated (Abstract #243). A heat shock protein 90 (HSP90) inhibitor (ganetespib) showed modest effects but was well tolerated making it available for use with conventional chemotherapy (Abstract #297). The details of these presentations will be discussed.

Image: University of Texas Southwestern Medical Center, Dallas, TX, USA


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Author Biography

Valerie Relias, Division of GI Oncology and Experimental Therapeutics, Tufts Medical Center. Boston, MA, USA




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University of Texas Southwestern Medical Center, Dallas, TX, USA
How to Cite
BrennanG., ReliasV., & SaifM. (2014). Novel Agents for the Treatment of Pancreatic Cancer. JOP. Journal of the Pancreas, 15(2), 110-113.
Highlights from the “2014 ASCO Gastrointestinal Cancers Symposium”. San Francisco, CA, USA. January 16-18, 2014

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