Biological Identification of Ampullary Adenocarcinomas
Abstract
Ampullary adenocarcinomas have unique biologic and clinical features that result in its improved prognosis versus adenocarcinomas that arise from the distal bile ducts and pancreas. However the histological differentiation and identification of these tumors is not easily accomplished. Two abstracts at this year’s ASCO Annual Meeting describe attempts to identify unique methods for distinguishing these tumors. Abstract #4141 described a 92 gene RT-PCR assay that was used for molecular classification of patients with ampullary adenocarcinomas while Abstract #e15175 looked at mutational status of K-ras in patients with these tumors. The results of their abstracts will be discussed.
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References
West gaard A, Pomianowska E, Clausen OPF, Gladhaug IP. Intestinal-type and pancreatobiliary-type adenocarcinomas: How does ampullary carcinoma differ from other periampullary malignancies? Ann Surg Oncol. 2013; 20:430-9. [PMID:22956064]
Todoroki T, Koike N, Morishita Y, Kawamoto T, Ohkohchi N, Shoda J, Fukuda Y, et al. Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater. Ann Surg Oncol. 2003; 10:1176-83. [PMID:14654474]
Kim WS, Choi DW, Choi SH, Heo JS, You DD, Lee HG. Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer. J Surg Oncol 2012; 105:266-72. [PMID:21882202]
Howe JR, Klimstra DS, Moccia RD, Conlon KC, Brennan MF. Factors predictive of survival in ampullary carcinoma. Annal of Surg 1998; 228:87-94. [PMID:9671071]
Schultz NA, Werner J, Willenbrock H, Roslind A, Giese N, Horn T, Wojdemann M, et al. MicroRNA expression profiles associated with pancreatic adenocarcinoma and ampullary adenocarcinoma. Mod Pathol 2012; 25:1609-22. [PMID:22878649]
Chang DK, Jamieson NB, Johns AL, Scarlett CJ, Pajic M, Chou A, Pinese M, et al. Histomolecular phenotypes and outcome in adenocarcinoma of the ampullar of Vater. J Clin Oncol. 2013; 31:1348-56. [PMID:23439753]
Schueneman A, Wang H, Soifer HS, Schnabel CA, Wolff RA, Varadhachary MJ, Overman MJ. Molecular classification of ampullary adenocarcinoma: Comparative prognostic performance of the 92-gene assay versus histomolecular analysis. J Clin Oncol. 2014; 32:5s (suppl; abstr 4141).
Sitthideatphaiboon P, Teerapakpinyo C, Klailaew N, Tanasanvimon S, Vinayanuwattikun C, Parinyanitikul N, Poovorawan N, et al. Prevalence of KRAS gene mutation in ampullary cancer in Thai patients. J Clin Oncol. 2014; 32 (suppl; abstr e15175).
Copyright (c) 2014 Valerie Relias, Muhammad Wasif Saif
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