Adjuvant Treatment for Ampullary Cancer

  • Richard Kim H. Lee Moffitt Cancer Center. Tampa, FL, USA
  • John Chabot Columbia University College of Physicians and Surgeons and New York Presbytarian Hospital. New York, NY, USA
  • Muhammad Wasif Saif Columbia University College of Physicians and Surgeons and New York Presbytarian Hospital. New York, NY, USA
Keywords: Ampulla of Vater, Drug Therapy, gemcitabine, Pancreatic Neoplasms


Ampullary cancer is an uncommon tumor and tends to have a better prognosis than pancreatic cancer. However, one half of patients will die from recurrent disease suggesting the need for effective adjuvant therapy. Currently, there is lack of randomized trials to guide the use of adjuvant therapy in ampullary cancer. At the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting, the largest trial (Abstract #4006) evaluating adjuvant treatment of ampullary cancer was presented.

Image: H. Lee Moffitt Cancer Center. Tampa, FL, USA.


Download data is not yet available.


Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients. Ann Surg 1995; 221:721-31.

Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006; 244:10-5.

Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Lillemoe KD, Pitt HA. Periampullary adenocarcinoma: Analysis of 5-year survivors. Ann Surg 1998; 227:821-31.

Lee JH, Whittington R, Williams NN, Berry MF, Vaughn DJ, Haller DG, et al. Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas. Int J Radiat Oncol Biol Phys 2000; 47:945-53.

Bhatia S, Miller RC, Haddock MG, Donohue JH, Krishnan S. Adjuvant therapy for ampullary carcinomas: The mayo clinic experience. Int J Radiat Oncol Biol Phys 2006; 66:514-9.

Klinkenbijl JH, Jeekel J, Sahmoud T, van Pel R, Couvreur ML, Veenhof CH, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase iii trial of the eortc gastrointestinal tract cancer cooperative group. Ann Surg 1999; 230:776-82.

Sikora SS, Balachandran P, Dimri K, Rastogi N, Kumar A, Saxena R, et al. Adjuvant chemo-radiotherapy in ampullary cancers. Ejso 2005; 31:158-63.

Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, et al. Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer - a randomized controlled trial. JAMA 2007; 297:267-77.

Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, Kato H, et al. Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase iii multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 2002; 95:1685-95.

Neoptolemos JP MM, Cox TF, Valle JW, Palmer DH, Mcdonald A, et al. Ampullary cancer espac-3 (v2) trial: A multicenter, international, open-label, randomized controlled phase iii trial of adjuvant chemotherapy versus observation in patients with adenocarcinoma of the ampulla of Vater. J Clin Oncol 2011; 29:Abstr LBA4006.

H. Lee Moffitt Cancer Center. Tampa, FL, USA
How to Cite
KimR., ChabotJ., & SaifM. (2011). Adjuvant Treatment for Ampullary Cancer. JOP. Journal of the Pancreas, 12(4), 362-363.
Highlights from the “2011 ASCO Annual Meeting”. Chicago, IL, USA. June 3-7, 2011