An Unusual Case of a Coexistent Serous Cystadenoma and Intraductal Papillary Mucinous Neoplasm of Pancreas. EUS to the Rescue!

  • Prabhleen Chahal Digestive Disease Institute, Cleveland Clinic Foundation. Cleveland, OH, USA
  • Assad J Saad Methodist Medical Center. Dallas, TX, USA
  • Rohan D Jeyarajah Methodist Medical Center. Dallas, TX, USA
Keywords: Cystadenoma, Serous, Neoplasms, Cystic, Mucinous, and Serous, Pancreatic Cyst

Abstract

Context Synchronous cystic neoplasms of pancreas are a highly rare occurrence. Case report We report a very rare case of coexistent serous cystadenoma and multi-side branch intraductal papillary mucinous neoplasm (IPMN). Conclusion To our knowledge, there has been only one previous case report in the literature of a synchronous serous cystadenoma and a solitary IPMN lesion. This case report is intended to increase the awareness of this condition while alluding to the need for diligent examination by endosonographers. It also highlights the clinical impact of endosonography on the diagnosis and management of cystic legions in the pancreas.

Image: Histological slide demonstrating synchronous IPMN and serous cystadenoma.

Downloads

Download data is not yet available.

References

Kim YW, Park YK, Lee S, Park JH, Lee SM, Hong SW, et al. Pancreatic endocrine tumor admixed with a diffuse microcystic adenoma. A case report. J Korean Med Sci 1997; 12:469-72. [PMID 9364309]

Blandamura S, Parenti A, Famengo B, Canesso A, Moschino P, Pasquali C, et al. Three cases of pancreatic serous cystadenoma and endocrine tumour. J Clin Pathol 2007; 60:278-82. [PMID 16644876]

Alasio TM, Vine A, Sanchez MA, Dardik H. Pancreatic endocrine tumor coexistent with serous microcystic adenoma: report of a case and review of the literature. Ann Diagn Pathol 2005; 9:234-8. [PMID 16084460]

Heresbach D, Robert I, Le Berre N, Raoul JL, Siproudhis L, Bretagne JF, et al. Cystic tumors and endocrine tumor of the pancreas. An unusual association. Gastroenterol Clin Biol 1993; 17:968-71. [PMID 8125232]

Hough DM, Stephens DH, Johnson CD, Binkovitz LA. Pancreatic lesions in von Hippel-Lindau disease: prevalence, clinical significance, and CT findings. AJR Am J Roentgenol 1994; 162:1091-4. [PMID 8165988]

Keel SB, Zukerberg L, Graeme-Cook F, Compton CC. A pancreatic endocrine tumor arising within a serous cystadenoma of the pancreas. Am J Surg Pathol 1996; 20:471-5. [PMID 8604814]

Ustün MO, Tuğyan N, Tunakan M. Coexistence of an endocrine tumour in a serous cystadenoma (microcystic adenoma) of the pancreas, an unusual association. J Clin Pathol 2000; 53; 800-2. [PMID 11064680]

Baek SY, Kang BC, Choi HY, Lee SW. Pancreatic serous cystadenoma associated with islet cell tumour. Br J Radiol 2000:73; 83-86. [PMID 10721327]

Slukvin II, Hafez GR, Niederhuber JE, Warner TF. Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literature. Arch Pathol Lab Med 2003; 127:1369-72. [PMID 14521452]

Goh BK, Tan YM, Kumarasinghe MP, Ooi LL. Synchronous serous cystadenoma and pancreatic endocrine tumor: a case report and literature review. Dig Dis Sci 2006; 51:422-6. [PMID 16534691]

Mohan H, Garg S, Punia RP, Dalal A. Combined serous cystadenoma and pancreatic endocrine neoplasm. A case report with a brief review of the literature. JOP. J Pancreas (Online) 2007; 8: 453-7. [PMID 17625299]

Agarwal N, Kumar S, Dass J, Arora VK, Rathi V. Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. JOP. J Pancreas (Online) 2009; 10:55-8. [PMID 19129617]

Goh BKP, Loh HL, Soo KC. Synchronous pancreatic serous cystic tumor, intraductal papillary mucinous tumor and gastric carcinoma: Report of a case. Pancreas 2005; 31:195-7. [PMID 16025009]

Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 1999; 94:470-3. [PMID 10022648]

Marrache F, Cazals-Hatem D, Kianmanesh R, Palazzo L, Couvelard A, O'Toole D, et al. Endocrine tumor and intraductal papillary mucinous neoplasm of the pancreas: a fortuitous association? Pancreas 2005; 31:79-83. [PMID 15968252]

Histological slide demonstrating synchronous IPMN and serous cystadenoma
Published
2011-05-06
How to Cite
ChahalP., SaadA., & JeyarajahR. (2011). An Unusual Case of a Coexistent Serous Cystadenoma and Intraductal Papillary Mucinous Neoplasm of Pancreas. EUS to the Rescue!. JOP. Journal of the Pancreas, 12(3), 244-246. https://doi.org/10.6092/1590-8577/3289
Section
CASE REPORT