Simultaneous Non-Functioning Neuroendocrine Carcinoma of the Pancreas and Extra-Hepatic Cholangiocarcinoma. A Case of Early Diagnosis and Favorable Post-Surgical Outcome

  • Simone Maurea Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Antonio Corvino Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Massimo Imbriaco Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Giuseppe Avitabile Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Pierpaolo Mainenti Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Luigi Camera Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
  • Gennaro Galizia Division of Surgical Oncology, F Magrassi A Lanzara Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine. Naples, Italy
  • Marco Salvatore Department of Biomorphological and Functional Sciences (DSBMF), University Federico II of Napoli (UNINA), Biostructures and Bioimages Institution (IBB), National Research Council (CNR); SDN Foundation (IRCCS). Naples, Italy
Keywords: Diagnostic Imaging, Magnetic Resonance Imaging, Neoplasms, Multiple Primary

Abstract

Context Thanks to the wide use of diagnostic imaging modalities, multiple primary malignancies are being diagnosed more frequently and different associations of malignancies have been reported in this setting. Case report In this paper, we describe the case of a patient with non-functioning well-differentiated neuroendocrine carcinoma of the head of the pancreas associated with extra-hepatic cholangiocarcinoma, in which an early diagnosis using magnetic resonance imaging allowed a good outcome. Conclusion The simultaneous association of neuroendocrine pancreatic tumors and cholangiocarcinoma has not yet been described; however, this association should be considered and, due to the high contrast of magnetic resonance imaging, this technique is recommended in such patient in order to reach an accurate diagnosis.

Image: T1-weighted fast-field echo short-time inversion recovery (FFE STIR) post-contrast image shows a solid lesion with inhomogeneous late-phase enhancement.

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References

De Angelis R, Grande E, Inghelmann R, Francisci S, Micheli A, Baili P, et al. Cancer prevalence estimates in Italy from 1970 to 2010. Tumori 2007; 93:392-7. [PMID 17899871]

Scotti A, Borrelli A, Tedesco G, Di Capua F, Cremone C, Iovino MG, Renda A. Multiple primary malignancies: ''Non-codified'' associations. In Renda A, ed. Updates in Surgery. Multiple Primary Malignancies. Chapter 13. Springer-Verlag, 2009:195-210. [ISBN 978-8847010949]

Billroth T. Die allgemeine chirurgische Pathologie und Therapie in funfzig Vorlesungen. Ein Handbuch fur Studierende und Arzte. Berlin: Verlag von Georg Reimer 1863. Auflage, p. 908.

Tammaro V, Spiezia S, D'Angelo S, Maurea S, Ciolli G, Salvatore M. Diagnostic imaging techniques for synchronous multiple tumors. In Renda A, ed. Updates in Surgery. Multiple Primary Malignancies. Chapter 16. Springer-Verlag, 2009:231-244. [ISBN 978-8847010949]

Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 1999; 94:470-3. [PMID 10022648]

Yamaguchi K, Yokohata K, Noshiro H, Chijiiwa K, Tanaka M. Mucinous cystic neoplasm of the pancreas intraductal papillary-mucinous tumor of the pancreas. Eur J Surg 2000; 166:141-8. [PMID 10724492]

Eguchi H, Ishikawa O, Ohigashi H, Tomimaru Y, Sasaki Y, Yamada T, et al. Patients with pancreatic intraductal papillary mucinous neoplasm are at high risk of colorectal cancer development. Surgery 2006; 139:749-54. [PMID 16782429]

Kamisawa T, Tu Y, Egawa N, Nakajima H, Tsuruta K, Okamoto A. Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2005; 11:5688-90. [PMID 16237766]

Herwick S, Miller FH, Keppke AL. MRI of islet cell tumors of the pancreas. AJR Am J Roentgenol 2006; 187:W472-80. [PMID 17056877]

Graziani R, Brandalise A, Bellotti M, Manfredi R, Contro A, Falconi M, et al. Imaging of neuroendocrine gastroenteropancreatic tumours. Radiol Med 2010; 115:1047-64. [PMID 20221711]

Kalb B, Sarmiento JM, Kooby DA, Adsay NV, Martin DR. MR imaging of cystic lesions of the pancreas. Radiographics 2009; 29:1749-65. [PMID 19959519]

T1-weighted fast-field echo short-time inversion recovery (FFE STIR) post-contrast image shows a solid lesion with inhomogeneous late-phase enhancement
Published
2011-05-06
How to Cite
MaureaS., CorvinoA., ImbriacoM., AvitabileG., MainentiP., CameraL., GaliziaG., & SalvatoreM. (2011). Simultaneous Non-Functioning Neuroendocrine Carcinoma of the Pancreas and Extra-Hepatic Cholangiocarcinoma. A Case of Early Diagnosis and Favorable Post-Surgical Outcome. JOP. Journal of the Pancreas, 12(3), 255-258. https://doi.org/10.6092/1590-8577/3292
Section
CASE REPORT