Diabetic Ketoacidosis Preceding Thrombocytopenia Associated Multiple Organ Failure in a Child

  • Kamakshya P Patra Department of Pediatrics, Louisiana State University Health Sciences Center. Shreveport, LA, USA
  • L Keith Scott Department of Pediatrics, Louisiana State University Health Sciences Center. Shreveport, LA, USA
Keywords: ADAMTS13 protein, human, Diabetic Ketoacidosis, Pancreatitis, Plasmapheresis, Thrombotic Microangiopathies


Context Thrombocytopenia associated multiple organ failure is a rare but increasingly recognized condition in children. Diabetic ketoacidosis preceding thrombocytopenia associated multiple organ failure is previously unreported in pediatric patients. Case report A 12-year-old female presented with diabetic ketoacidosis along with acute pancreatitis. She further developed thrombocytopenia and renal failure over the next two days. Although hemolytic uremic syndrome/thrombotic thrombocytopenic purpura spectrum was considered, the clinical picture seemed most consistent with thrombocytopenia associated multiple organ failure. The patient was treated with serial therapeutic plasma exchanges and made a complete recovery. Conclusion A high index of suspicion of thrombocytopenia associated multiple organ failure is required in patients with diabetic ketoacidosis or pancreatitis who present with thrombocytopenia and renal failure. Plasma exchange is a life-saving intervention in such cases.

Image: Diffuse enlargement and hypoattenuation of pancreas.


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Diffuse enlargement and hypoattenuation of pancreas
How to Cite
PatraK., & ScottL. (2011). Diabetic Ketoacidosis Preceding Thrombocytopenia Associated Multiple Organ Failure in a Child. JOP. Journal of the Pancreas, 12(1), 40-43. https://doi.org/10.6092/1590-8577/3382