Tumor Size and Diabetes Are the Most Important Pre-Operative Prognostic Factors Influencing Survival After Pancreaticoduodenectomy in Pancreas Cancer Patients

  • Marco Del Chiaro Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
  • Elena Rangelova Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
  • Christoph Ansorge Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
  • John Blomberg Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
  • Ralf Segersvärd Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Keywords: Meeting Abstracts, Pancreas

Abstract

Context The median survival in resected pancreatic ductal adenocarcinoma (PDAC) is about two years. However, a considerable percentage of patients die within the first year after resection. Objective The aim of this study was to evaluate pre-operative factors predicting a short survival after pancreatico­duodenectomy (PD) for PDAC. Methods One hundred consecutive patients undergone PD for PDAC without in-hospital mortality from October 2006 to July 2010 were retrieved from our prospective database. The cohort was divided by survival into short term (≤12 months: group A) and long term (>12 months: group B) survivors and evaluated regarding pre-operative factors including age, weight loss, BMI, tumor size and proximity (no contact-contact) to the portal/mesenteric vein (PV/SMV). Results No significant differences were found between group A (n=27) and group B (n=73) regarding mean age (68±2 vs. 66±1 years; P=0.3), weight loss (87% vs. 85%; P=1.0), BMI (24±0.6 kg/m2 vs. 24±0.5 kg/m2; P=0.7) or adjuvant treatment. Group A had bigger tumors (35±2 mm vs. 29±1 mm; P=0.01) but no significant difference in proximity of the tumor to the PV/SMV (contact: A 67% vs. B 49%; P=0.2) or venous resections. Group A had more frequently pre-operative diabetes (33% vs. 9.6%; P=0.01) compared to group B. Conclusion Tumor size and pre-operative diabetes seems to be important negative prognostic factors for survival after PD for PDAC.

Downloads

Download data is not yet available.

Author Biographies

Marco Del Chiaro, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Karolinska University Hospital
Department of Surgical Gastroenterology
SE-141 86 Stockholm, Sweden
Elena Rangelova, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Karolinska University Hospital
Department of Surgical Gastroenterology
SE-141 86 Stockholm, Sweden
Christoph Ansorge, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Karolinska University Hospital
Department of Surgical Gastroenterology
SE-141 86 Stockholm, Sweden
John Blomberg, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Karolinska University Hospital
Department of Surgical Gastroenterology
SE-141 86 Stockholm, Sweden
Published
2012-09-20
How to Cite
Del ChiaroM., RangelovaE., AnsorgeC., BlombergJ., & SegersvärdR. (2012). Tumor Size and Diabetes Are the Most Important Pre-Operative Prognostic Factors Influencing Survival After Pancreaticoduodenectomy in Pancreas Cancer Patients. JOP. Journal of the Pancreas, 13(5S), 606. https://doi.org/10.6092/1590-8577/961