A Dog Model of Pancreaticojejunostomy Without Duct-to-Mucosa Anastomosis

  • Sung Hoon Choi Division of Hepatobiliary and Pancreas, Department of Surgery1 and Pathology2, Yonsei University College of Medicine,
  • Jun Jeong Choi
  • Chang Moo Kang Department of Surgery, Yonsei University College of Medicine, Seoul, Korea Institute of Gastroenterology, Yonsei University Health System, Seoul, Korea (Ludlow Faculty Research Building #204) Tel: +82-2-2228-2135 Fax: +82-2-313-8289
  • Ho Kyoung Hwang
  • Woo Jung Lee
Keywords: Models, Animal, Pancreatic Fistula, Pancreaticojejunostomy


Context Various anastomosis techniques have been introduced for the safe pancreaticoenterostomy. Objective In the present study, we developed an experimental animal model for simple pancreaticojejunostomy and evaluated the feasibility, safety, and efficacy of this technique. Animals Ten dogs were studied. Intervention The dogs underwent the simple approximation (“docking”) method for pancreaticojejunostomy and were re-explored on the 30th post-operative day. Main outcome measure After excision of the remnant pancreas with the jejunal segment of the pancreaticojejunostomy, the degrees of fibrosis in the remnant pancreas were analyzed according to the patency of the pancreaticojejunostomy. Results There were no mortalities and clinically significant complications. The patency of pancreaticojejunostomy remained in six cases and was obliterated in four cases. It was noted that obliterated pancreaticojejunostomy accompanied cases with more dilated pancreatic ducts (3.1±0.4 mm vs. 5.5±0.6 mm, P=0.008). The grade of pancreatic fibrosis was significantly correlated with the obliterated pancreaticojejunostomy (P=0.038) and the size change of the remnant pancreatic duct (P=0.040). Conclusions The suggested simple pancreaticojejunostomy method is easy and shows no evidence of significant pancreatic fistula. However, the potential risk of dysfunction in the remnant pancreas limits its possible clinical applications. The meticulous duct-to-mucosa pancreaticojejunostomy is highly preferred to manage the remnant pancreas following pancreaticoduodenectomy.


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Clear pancreatic juice from the inserted pancreatic duct stent
How to Cite
ChoiS., ChoiJ., KangC., HwangH., & LeeW. (2012). A Dog Model of Pancreaticojejunostomy Without Duct-to-Mucosa Anastomosis. JOP. Journal of the Pancreas, 13(1), 30-35. https://doi.org/10.6092/1590-8577/597