18F-FDG PET/CT Imaging of the Pancreas: Spectrum of Diseases

  • Vien X Nguyen Mayo Clinic Arizona Departments of Gastroenterology and Hepatology 13400 East Shea Blvd Scottsdale, AZ 85259 USA Phone: +1-480-301-6990 Fax: +1-480-301-6737 E-mail: vnguy01@gmail.com
  • Cuong C Nguyen
  • Ba D Nguyen
Keywords: Fluorodeoxyglucose F18, Neoplasm Metastasis, Pancreas, Pancreatic Neoplasms, Positron-Emission Tomography, Tomography, X-Ray Computed


Since the introduction of integrated positron emission tomography-computed tomography (PET/CT), it has a great impact on the field of oncology. Comparing to other conventional scanners, only PET/CT is capable of providing important information on accurate detecting, staging/restaging, and post-therapeutic monitoring of many cancers. Many studies have demonstrated that PET/CT changes the management in approximately 30% of all cancer patients. Because 2-(18F)-fluoro-2-deoxy-D-glucose (FDG) is a nonspecific tracer, understanding the PET/CT limitations and pitfalls for various pancreatic conditions can lead to more accurate interpretation of PET/CT images, which ultimately would impact patient care. As a result, it is important for radiologists and other clinicians to familiarize themselves with a wide spectrum of pancreatic PET/CT findings simulating cancer from benign entities.


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Delbeke D, Martin WH. PET and PET/CT for pancreatic malignancies. Surg Oncol Clin N Am 2010; 19:235-54. [PMID 20159513]

Gu P, Pan LL, Wu SQ, Sun L, Huang G. CA 125, PET alone, PET-CT, CT and MRI in diagnosing recurrent ovarian carcinoma: a systematic review and meta-analysis. Eur J Radiol 2009; 71:164-74. [PMID 18378417]

Casneuf V, Delrue L, Kelles A, Van Damme N, Van Huysse J, Berrevoet F, et al. Is combined 18F-fluorodeoxyglucose-positron emission tomography/computed tomography superior to positron emission tomography or computed tomography alone for diagnosis, staging and restaging of pancreatic lesions? Acta Gastroenterol Belg 2007; 70:331-8. [PMID 18330088]

Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol 2008; 14:3948-55. [PMID 18609677]

Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK, et al. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all 'chronic pancreatitis'? Am J Surg Pathol 2003; 27:110-20. [PMID 12502933]

Tsitouridis I, Diamantopoulou A, Michaelides M, Arvanity M, Papaioannou S. Pancreatic metastases: CT and MRI findings. Diagn Interv Radiol 2010; 16:45-51. [PMID 20027546]

Jerjes W, Upile T, Petrie A, Riskalla A, Hamdoon Z, Vourvachis M, et al. Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head Neck Oncol 2010; 2:9. [PMID 20406474]

Kim SY, Roh JL, Yeo NK, Kim JS, Lee JH, Choi SH, Nam SY. Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Ann Oncol 2007; 18:1698-703. [PMID 17716985]

Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch 2004; 444:527-35. [PMID 15057558]

Durie BG. The role of anatomic and functional staging in myeloma: description of Durie/Salmon plus staging system. Eur J Cancer 2006; 42:1539-43. [PMID 16777405]

Webb TH, Lillemoe KD, Pitt HA, Jones RJ, Cameron JL. Pancreatic lymphoma. Is surgery mandatory for diagnosis or treatment? Ann Surg 1989; 209:25-30. [PMID 2910212]

Sohn TA, Yeo CJ, Cameron JL, Nakeeb A, Lillemoe KD. Renal cell carcinoma metastatic to the pancreas: results of surgical management. J Gastrointest Surg 2000; 5:346-51. [PMID 11985973]

Reinhardt MJ, Joe AY, Jaeger U, Huber A, Matthies A, Bucerius J, et al. Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients. J Clin Oncol 2006; 24:1178-87. [PMID 16505438]

Choi JY, Lee KS, Kwon OJ, Shim YM, Baek CH, Park K, et al. Improved detection of second primary cancer using integrated (18F) fluorodeoxyglucose positron emission tomography and computed tomography for initial tumor staging. J Clin Oncol 2005; 23:7654-9. [PMID 16234527]

Fused axial PET/CT image reveals the hypermetabolic pancreatic malignancy
How to Cite
NguyenV., NguyenC., & NguyenB. (1). 18F-FDG PET/CT Imaging of the Pancreas: Spectrum of Diseases. JOP. Journal of the Pancreas, 12(6), 557-566. https://doi.org/10.6092/1590-8577/554