Lipemic Serum in a Toddler with New-Onset Diabetes Mellitus Presenting with Diabetic Ketoacidosis
Abstract
Context Significant hyperlipidemia causing lipemic serum in patients with poorly controlled diabetes is under-reported in children. The recognition of the severe hyperlipidemia is important for proper management and to prevent associated morbidities. Severe hyperlipidemia in patients with diabetic ketoacidosis should be considered. Case report In this case we report a 2-year-old girl with new onset type 1 diabetes mellitus, who presented with severe diabetic ketoacidosis and hyperlipidemia. Hyperlipidemia was resolved with hydration and insulin therapy. Conclusion It is important to diagnose hyperlipidemia by checking serum lipid profile for all pediatric patients presenting with hyperglycemic crisis to prevent morbidities.Downloads
References
Rewers A, Klingensmith G, Davis C, et al. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study. Pediatrics. May 2008;121(5):e1258-66.
Smith CP, Firth D, Bennett S, et al. Ketoacidosis occurring in newly diagnosed and established diabetic children. Acta Paediatr. May 1998;87(5):537-541.
Rewers A, Chase HP, Mackenzie T, et al. Predictors of acute complications in children with type 1 diabetes. JAMA. May 15 2002;287(19):2511-2518.
Trachtenbarg DE. Diabetic ketoacidosis. Am Fam Physician. 2005;71:1705-1714.
Potter JL, Stone RT. Massive hyperlipidemia in diabetic ketoacidosis. The clinical importance of laboratory recognition. Clin Pediatr (Phila). 1975;14:412-413.
Nyamugunduru G, Roper H. A difficult case. Childhood onset insulin dependent diabetes presenting with severe hyperlipidaemia. BMJ. 1997;314(7073):62-65.
Farese RV Jr; Yost TJ; Eckel RH. Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans. Metabolism 1991;40:214-216.
Hsu JH, Wu JR, Chao MC, Dai ZK, Chiou SS, Chen BH. Severe hyperlipidaemic pancreatitis associated with diabetes. Acta Paediatr. 2006;95:378-379.
Koul PB, Sussmane JB. Metabolic hyperglycemic emergencies with acute pancreatitis in a child with known insulin-dependent diabetes mellitus. Eur J Emerg Med. 2005 ;12:309-311.
Shenoy SD, Cody D, Rickett AB, Swift PG. Acute pancreatitis and its association with diabetes mellitus in children. J Pediatr Endocrinol Metab. 2004;17:1667-1670.
Nair S, Pitchumoni CS. Diabetic ketoacidosis, hyperlipidemia, and acute pancreatitis: the enigmatic triangle. Am J Gastroenterol. 1997;92:1560-1561.
Karagianni C, Stabouli S, Roumeliotou K, Traeger-Synodinos J, Kavazarakis E, Gourgiotis D, et al. Severe hypertriglyceridaemia in diabetic ketoacidosis: clinical and genetic study. Diabet Med. 2004;21:380-382.
Copyright (c) 2014 Muhammad Waseem, Swati Dave-Sharma, Lin Lin Kin, Fernando Jara
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