Isoniazid-Induced Recurrent Pancreatitis

Sarah Mattioni; Michele Zamy; Frederic Mechai; Jean-Jacques Raynaud; Amelie Chabrol; Vanessa Aflalo; Michel Biour; Olivier Bouchaud

doi:10.6092/1590-8577/813

Sarah Mattioni Department of Infectious Diseases, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13. Bobigny, France
Michele Zamy Department of Pharmocology, Hospital Saint- Antoine, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 6, Paris, France.
Frederic Mechai Department of Infectious Diseases, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13, Bobigny, France
Jean-Jacques Raynaud Department of Gastroenterology, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13, Bobigny, France.
Amelie Chabrol Department of Infectious Diseases, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13, Bobigny, France
Vanessa Aflalo Department of Radiology, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13, Bobigny, France
Michel Biour Department of Pharmocology, Hospital Saint- Antoine, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 6, Paris, France
Olivier Bouchaud Department of Infectious Diseases, Hospital Avicenne, Assistance Publique, Hôpitaux de Paris (AP-HP), University of Paris 13, Bobigny, France

DOI: https://doi.org/10.6092/1590-8577/813

Keywords: Isoniazid /adverse effects, Pancreatitis, Tuberculosis

Abstract

Context Drug induced pancreatitis are rare but potentially serious. Thus, drug withdrawal is warranted. Case report A 79-year-old woman who was treated with antituberculosis therapy for 5 weeks was admitted to our unit for pancreatitis. Usual etiologies of pancreatitis were eliminated. Because of vomiting, antituberculosis therapy was withdrawn and symptoms disappeared. Eight days later, the same treatment was reintroduced and the patient presented recurrent pancreatitis; thus, treatment was withheld again followed by disappearance of clinical and biological abnormalities. Two days later, a treatment without isoniazid was reintroduced and no recurrence of symptoms was observed. Conclusions We have experienced a case of isoniazid induced pancreatitis. This is a rare cause of pancreatitis but potentially fatal thus recognition of drug induced pancreatitis and definitive withdrawal of the drug is required.

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