Multiple Extrasplanchnic Venous Thromboses: A Rare Complication of Pancreatitis. A Case Report
Abstract
Context Venous thrombosis has been described in patients with acute and chronic pancreatitis. This is especially common in portal vein, splenic vein and superior mesenteric vein. To the best of our knowledge, involvement of superior vena cava and subclavian vessel due to pancreatitis has not been reported. Case report We present here a case of an adult male with alcoholic chronic pancreatitis who presented with multiple vessel thromboses involving superior vena cava, inferior vena cava, bilateral subclavian, internal jugular vein, axillary, iliac and renal vein without involvement of portal, splenic and superior mesenteric vein that was effectively treated with i.v. anticoagulation therapy. Conclusion Venous thromboses can occur outside the splanchnic circulation in pancreatitis.
Downloads
References
Butler JR, Eckert GJ, Zyromski NJ, Leonardi MJ, Lillemoe KD, Howard TJ. Natural history of pancreatitis-induced splenic vein thrombosis: a systematic review and meta-analysis of its incidence and rate of gastrointestinal bleeding. HPB (Oxford) 2011;13:839-45.PMID: 22081918 PMCID: PMC3244622
Nicolas de Prado I, Corral de la Calle MA, Nicolas de Prado JM, Gallardo Sanchez F, Medranda MA. [Vascular complications of pancreatitis]. Rev Clin Esp 2005;205:326-32. PMID:16029759.
Nordback I, Sisto T. Peripancreatic vascular occlusions as a complication of pancreatitis. Int Surg 1989;74:36-9. PMID: 2707996.
Ma SK, Kim SW, Kim NH, Choi KC. Renal vein and inferior vena cava thrombosis associated with acute pancreatitis. Nephron 2002;92:475-7. PMID: 12218335.
Besselink MG. Splanchnic vein thrombosis complicating severe acute pancreatitis. HPB (Oxford) 2011;13:831-2. PMID: 12218335.
Gonzelez HJ, Sahay SJ, Samadi B, Davidson BR, Rahman SH. Splanchnic vein thrombosis in severe acute pancreatitis: a 2-year, single-institution experience. HPB (Oxford) 2011;13:860-4. PMID: 22081920. PMCID:PMC3244624
Stringer MD, Michell M, McIrvine AJ. Inferior vena caval thrombosis complicating acute pancreatitis. Case report. Acta Chir Scand 1988;154:161-3. PMID:3354298
Ohta H, Hachiya T. A case of inferior vena cava thrombosis and pulmonary embolism secondary to acute exacerbation of chronic pancreatitis: a rare finding in radionuclide venography. Ann Nucl Med 2002;16:147-9. PMID:12043910.
Peillon C, Manouvrier JL, Testart J. Inferior vena cava thrombosis secondary to chronic pancreatitis with pseudocyst. Am J Gastroenterol 1991;86:1854-6. PMID: 1962640.
Jorge Cerrudo J, Mansilla Rosello A, Paz Yanez A, Segura Jimenez I, Ferron Orihuela JA. Urgent vascular complications in acute pancreatitis. Cir Esp 2012;90:134-6. PMID: 21414617[Pub Med - in process]
Zhang Q, Zhang QX, Tan XP, et al. Pulmonary embolism with acute pancreatitis: A case report and literature review. World J Gastroenterol 2012;18:583-6.
Orr DW, Patel RK, Lea NC, et al. The prevalence of the activating JAK2 tyrosine kinase mutation in chronic porto-splenomesenteric venous thrombosis. Aliment Pharmacol Ther 2010;31:1330-6. PMID: 20331577.
Jiao HB, Qiao Z, Tan XL, et al. [Effects of anticoagulation therapy with low molecular weight heparin in acute pancreatitis]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004;16:712-4. PMID: 15585141.
Alvi AR, Bibi S, ur Rehman Z, Niazi SK. Acute mesenteric, portal and inferior vena cava (IVC) venous thrombosis: optimal outcome achieved with anticoagulation. J Pak Med Assoc 2010;60:397-9. PMID: 20527618.
Copyright (c) 2014 Hardik Parikh, Akash Shukla, Yashant Aswani, Shobna Bhatia
This work is licensed under a Creative Commons Attribution 4.0 International License.
As a member of Publisher International Linking Association, PILA, iMedPub Group’s JOP follows the Creative Commons Attribution License and Scholars Open Access publishing policies. Journal of the Pancreas is the Council Contributor Member of Council of Science Editors (CSE) and following the CSE slogan Education, Ethics, and Evidence for Editors.