HBV- and HCV-Related Infections and Risk of Pancreatic Cancer

  • Sirio Fiorino Unit of Internal Medicine, Hospital of Budrio. Budrio, BO, Italy
  • Andrea Cuppini Unit of Internal Medicine, Hospital of Budrio. Budrio, BO, Italy
  • Gastone Castellani Fisics, “Alma Mater Studiorum” – University of Bologna, S. Orsola-Malpighi Hospital. Bologna, Italy
  • Maria Letizia Bacchi-Reggiani Cardiology, “Alma Mater Studiorum” – University of Bologna, S. Orsola-Malpighi Hospital. Bologna, Italy
  • Elio Jovine Unit of General Surgery, Maggiore Hospital. Bologna, Italy
Keywords: Carcinoma, Hepatocellular, Hepacivirus, Hepatitis B virus, Pancreatic Carcinoma, Pancreatic Neoplasms, Risk Factors


Pancreatic carcinoma is one of the most lethal cancers in humans. The poor prognosis of this malignancy depends on several factors, such as: lack of early symptoms, advanced stage at detection, early metastatic spread and no effective systemic treatment. To date, only few risk factors for this malignancy are known; therefore, considerable efforts are required to identify additional causative agents involved in the process of pancreatic carcinogenesis. In the last years, a large series of epidemiological investigations have suggested that both bacteria and viruses may play a important role in the initiation and progression of several animal and human cancers. In particular, some studies have showed that hepatitis B (HBV) and hepatitis C (HCV) viruses, two hepatotropic pathogens with well-known oncogenic properties for liver, may be detected also in extra-hepatic tissues, such as pancreas. The aim of this paper is to briefly report the results of available studies, assessing the possible association between HBV/HCV and pancreatic cancer development as well as to discuss the limiting factors of these researches.

Image: Hepatitis C virus.


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Hepatitis C virus
How to Cite
FiorinoS., CuppiniA., CastellaniG., Bacchi-ReggianiM. L., & JovineE. (2013). HBV- and HCV-Related Infections and Risk of Pancreatic Cancer. JOP. Journal of the Pancreas, 14(6), 603-609. https://doi.org/10.6092/1590-8577/1948

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