HBV- and HCV-Related Infections and Risk of Pancreatic Cancer

  • Sirio Fiorino Unit of Internal Medicine, Hospital of Budrio. Budrio, BO, Italy
  • Andrea Cuppini Unit of Internal Medicine, Hospital of Budrio. Budrio, BO, Italy
  • Gastone Castellani Fisics, “Alma Mater Studiorum” – University of Bologna, S. Orsola-Malpighi Hospital. Bologna, Italy
  • Maria Letizia Bacchi-Reggiani Cardiology, “Alma Mater Studiorum” – University of Bologna, S. Orsola-Malpighi Hospital. Bologna, Italy
  • Elio Jovine Unit of General Surgery, Maggiore Hospital. Bologna, Italy
Keywords: Carcinoma, Hepatocellular, Hepacivirus, Hepatitis B virus, Pancreatic Carcinoma, Pancreatic Neoplasms, Risk Factors

Abstract

Pancreatic carcinoma is one of the most lethal cancers in humans. The poor prognosis of this malignancy depends on several factors, such as: lack of early symptoms, advanced stage at detection, early metastatic spread and no effective systemic treatment. To date, only few risk factors for this malignancy are known; therefore, considerable efforts are required to identify additional causative agents involved in the process of pancreatic carcinogenesis. In the last years, a large series of epidemiological investigations have suggested that both bacteria and viruses may play a important role in the initiation and progression of several animal and human cancers. In particular, some studies have showed that hepatitis B (HBV) and hepatitis C (HCV) viruses, two hepatotropic pathogens with well-known oncogenic properties for liver, may be detected also in extra-hepatic tissues, such as pancreas. The aim of this paper is to briefly report the results of available studies, assessing the possible association between HBV/HCV and pancreatic cancer development as well as to discuss the limiting factors of these researches.

Image: Hepatitis C virus.

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References

Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43-66.

Krejs GJ. Pancreatic cancer: epidemiology and risk factors. Dig Dis 2010;28:355-8.

Schnelldorfer T, Ware AL, Sarr MG, Smyrk TC, Zhang L, Qin R, Gullerud RE, Donohue JH, Nagorney DM, Farnell MB. Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg. 2008;247(3):456-62.

Hidalgo M. Pancreatic cancer. N Engl J Med 2010 29;362:1605-17.

Li D, Day RS, Bondy ML, Sinha R, Nguyen NT, Evans DB et al. Dietary mutagen exposure and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:655-61

Jacobs EJ, Rodriguez C, Newton CC, Bain EB, Patel AV, Feigelson HS et al. Family history of various cancers and pancreatic cancer mortality in a large cohort. Cancer Causes Control. 2009;20:1261-69.

Larghi A, Verna EC, Lecca PG, Costamagna G. Screening for pancreatic cancer in high-risk individuals: a call for endoscopic ultrasound. Clin Cancer Res 2009;15:1907-14.

Apte M, Pirola R, Wilson J. New insights into alcoholic pancreatitis and pancreatic cancer. J Gastroenterol Hepatol. 2009;24:S51-56.

Chari ST, Leibson CL, Rabe KG, Timmons LJ, Ransom J, de Andrade M et al. Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology 2008;134:95-101.

Rosato V, Tavani A, Bosetti C, Pelucchi C, Talamini R, Polesel J et al. Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis. Metabolism 2011; 60: 1372-8.

Johansen D, Stocks T, Jonsson H, Lindkvist B, Björge T, Concin H et al. Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project. Cancer Epidemiol Biomarkers Prev 2010; 19: 2307-17.

Lowenfels AB, Maisonneuve P, Lankisch PG. Chronic pancreatitis and other risk factors for pancreatic cancer. Gastroenterol Clin North Am 1999; 28:673-85.

Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med. 2000;248(3):171-83.

Trikudanathan G, Philip A, Dasanu CA, Baker WL. Association between Helicobacter pylori Infection and Pancreatic Cancer. A Cumulative Meta-Analysis. J Pancreas 2011; 12: 26-31.

Marshall BJ. Helicobacter pylori. Am J Gastroenterol 1994; 89(8 Suppl):S116-28.

Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 2007; 133: 659-72

Michaud DS, Joshipura K, Giovannucci E, Fuchs CS. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst 2007; 99: 171-5.

Stolzenberg-Solomon RZ, Dodd KW, Blaser MJ, Virtamo J, Taylor PR, Albanes D. Tooth loss, pancreatic cancer and Helicobacter Pylori. Am J Clin Nutr 2003; 78: 176-81.

Farrell JJ, Zhang L, Zhou H, Chia D, Elashoff D, Akin D et al. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut 2012; 61: 582-88.

Serraino D, Dal Maso L, De Paoli A, Zucchetto A, Bruzzone S, Camoni L et al. On changes in cancer mortality among HIV-infected patients: is there an excess risk of death from pancreatic cancer? Clin Infect Dis 2009; 49: 481-482.

Engels EA, Biggar RJ, Hall HI, Cross H, Crutchfield A, Finch JL, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer 2008; 123: 187-94.

Simard EP, Pfeiffer RM, Engels EA. Spectrum of cancer risk late after AIDS onset in the United States. Arch Intern Med. 2010; 170: 1337-45.

Hussain SP, Harris CC. Inflammation and cancer: an ancient link with novel potentials. Int J Cancer 2007;121(11):2373-80

Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut 2012; 2012;61 Suppl 1:i6-17. doi: 10.1136/gutjnl-2012-302056.

Poynard T, Ratziu V, Charlotte F, Goodman Z, McHutchison J, Albrecht J. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C. J Hepatol 2001; 34: 730-9.

Zhou Y, Zhao Y, Li B, Huang J, Wu L, Xu D, Yang J, He J. Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis. BMC Cancer. 2012 Jul 16;12:289. doi: 10.1186/1471-2407-12-289.

Jeong SH. HBV infection as a risk factor for non-Hodgkin lymphoma. Lancet Oncol. 2010;11(9):806. doi: 10.1016/S1470-2045(10)70182-0.

Fiorilli M, Mecucci C, Farci P, Casato M. HCV-associated lymphomas. Rev Clin Exp Hematol. 2003;7(4):406-23.

Jin Y, Gao H, Chen H, Wang J, Chen M, Li G, Wang L, Gu J, Tu H. Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues. Cancer Lett. 2013. pii: S0304-3835(13)00224-3. doi: 10.1016/j.canlet.2013.03.001.

Yan FM, Chen AS, Hao F, Zhao XP, Gu CH, Zhao LB et al. Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis C. World J Gastroenterol. 2006:805-11.

Alvares-Da-Silva MR, Francisconi CF, Waechter FL. Acute hepatitis C complicated by pancreatitis: another extrahepatic manifestation of hepatitis C virus? J Viral Hepat. 2000;7(1):84-6.

Yuen MF, Chan TM, Hui CK, Chan AO, Ng IO, Lai CL. Acute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosis. J Viral Hepat. 2001;8(6):459-64.

Parsa I, Longnecker DS, Scarpelli DG, Pour P, Reddy JK, Lefkowitz M. Ductal metaplasia of human exocrine pancreas and its association with carcinoma. Cancer Res. 1985;45(3):1285-90.

Reichert M, Rustgi AK. Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest. 2011;121(12):4572-8. doi: 10.1172/JCI57131.

Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet. 2008;9(5):329-40

Wandzioch E, Zaret KS. Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science 2009;324(5935):1707-10

Dabeva MD, Hwang SG, Vasa SR et al. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci U S A. 1997;94(14):7356-61.

Wang RY, Shen CN, Lin MH, Tosh D, Shih C. Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus. J Virol. 2005;79(20):13116-28.

Shimoda T, Shikata T, Karasawa T, Tsukagoshi S, Yoshimura M, Sakurai I. Light microscopic localization of hepatitis B virus antigens in the human pancreas. Possibility of multiplication of hepatitis B virus in the human pancreas. Gastroenterology 1981;81(6): 998-1005.

Dejean A, Lugassy C, Zafrani S, Tiollais P, Brechot C. Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus. J Gen Virol. 1984;65 (Pt 3): 651-5.

Hohenberger P. The pancreas as target organ for hepatitis B virus-immunohistological detection of HBsAg in pancreatic carcinoma and chronic pancreatitis. Leber Magen Darm. 1985;15(2):58-63

Fiorino S, Lorenzini S, Masetti M, Deleonardi G, Grondona AG, Silvestri T, Chili E, Del Prete P, Bacchi-Reggiani L, Cuppini A, Jovine E. Hepatitis B and C virus infections as possible risk factor for pancreatic adenocarcinoma. Med Hypotheses. 2012, 79: 678-697.

Hassan MM, Li D, El-Deeb AS, Wolff RA, Bondy ML, Davila M et al. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol 2008; 26:4557-62.

Iloeje UH, Yang HI, Jen CL, Su J, Wang LY, You SL, Lu SN, Chen CJ. Risk of pancreatic cancer in chronic hepatitis B virus infection: data from the REVEAL-HBV cohort study Liver Int. 2010; 30 (3): 423–9.

Wang DS, Chen DL, Ren C, Wang ZQ, Qiu MZ, Luo HY, Zhang DS, Wang FH, Li YH, Xu RH. ABO blood group, hepatitis B viral infection and risk of pancreatic cancer. Int J Cancer. 2012;131(2):461-8

Ben Q, Li Z, Liu C, Cai Q, Yuan Y, Wang K, Xiao L, Gao J, Zhang H. Hepatitis B virus status and risk of pancreatic ductal adenocarcinoma: a case-control study from China. Pancreas. 2012; 41(3):435-40.

El-Serag HB, Engels EA, Landgren O, Chiao E, Henderson L, Amaratunge HC et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology 2009;49:116-23.

Zhu F, Li HR, Du GN, Chen JH, Cai SR. Chronic hepatitis B virus infection and pancreatic cancer: a case-control study in southern China. Asian Pac J Cancer Prev. 2011;12(6):1405-8.

Woo SM, Joo J, Lee WJ, Park SJ, Han SS, Kim TH et al. Risk of pancreatic cancer in relation to ABO blood group and hepatitis C virus infection in Korea: a case-control study. J Korean Med Sci. 2013;28(2):247-51. doi: 10.3346/jkms.2013.28.2.247.

Ma W, Xie D, Cao W, Yang Q, Jiang Z, Chen D et al. Association between hepatitis B virus infection and pancreatic cancer. Chinese Journal of Clinical Oncology 2009 36:24 (1388-1390).

Hong SG, Kim JH, Lee YS, Yoon E, Lee HJ, Hwang JK et al. The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study. Korean J Hepatol. 2010;16(1):49-56.

Xu P, Huang Q, Liu C, Xie F, Shao F, Zhu C et al. Risk factors for pancreatic cancer: a case-control study. Cancer (Chinese J) 2011; 31: 653-7.

Tang J, Lamerato L, Sheehan MJ, Krajenta R, Gordon SC. Is previous exposure to hepatitis B a risk factor for pancreatic cancer? Hepatology 2009; 50: 988A

Chang YT, Hsu C, Wei SC, Huang GT, Hsu JC, Wong JM et al. Chronic hepatitis B and hepatitis C virus infection are not associated with pancreatic cancer in Taiwan-A high endemic area. Pancreatology 2009; 9: 518A.

Berrington de Gonzalez A, Yun JE, Lee SY, Klein AP, Jee SH. Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study. Cancer Epidemiol Biomarkers Prev 2008;17:359-64.

Wang Y, Yang Sl, Song FJ, Cao SY, Yin X, Xie J. et al. Hepatitis B virus status and the risk of pancreatic cancer: a meta-analysis. Eur J Cancer Prev 2012.

Luo G , Hao NB , Hu CJ , Yong X , Lü MH , Cheng BJ, et al. HBV infection increases the risk of pancreatic cancer: a meta-analysis. Cancer Causes Control 2013; 24: 529-37.

Li L, Wu B, Yang LB, Yin GC, Liu JY. Chronic Hepatitis B virus infection and risk of pancreatic cancer: a meta-analysis. Asian Pac J Cancer Prev. 2013; 14: 275-279.

Fiorino S, Chili E, Bacchi-Reggiani L, Masetti M, Deleonardi G, Grondona AG, et al. Association between hepatitis B or hepatitis C virus infection and risk of pancreatic adenocarcinoma development: A systematic review and meta-analysis. Pancreatology 2013; 2: 147-60.

Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, et al. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009; 27(47):6550-7.

Centers for Disease Control and Prevention (CDC). Screening for chronic hepatitis B among Asian/Pacific Islander populations--New York City, 2005. MMWR Morb Mortal Wkly Rep. 2006;55(18):505-9.

Larrubia JR. Occult hepatitis B virus infection: a complex entity with relevant clinical implications. World J Gastroenterol. 2011;17(12):1529-30.

Hepatitis C virus
Published
2013-11-10
How to Cite
FiorinoS., CuppiniA., CastellaniG., Bacchi-ReggianiM. L., & JovineE. (2013). HBV- and HCV-Related Infections and Risk of Pancreatic Cancer. JOP. Journal of the Pancreas, 14(6), 603-609. https://doi.org/10.6092/1590-8577/1948
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