Updates in Management of Ampullary Carcinomas

  • Preethi K John Department of Medicine and Cancer Center, Tufts Medical Center. Boston, MA, USA
  • Andromachi S Kougioumtzopoulou Radiotherapy Unit, Second Department of Radiology, Attikon General Hospital. Athens, Greece
  • Konstantinos N Syrigos Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital. Athens, Greece
  • Muhammad Wasif Saif Department of Medicine and Cancer Center, Tufts Medical Center. Boston, MA, USA
Keywords: Ampulla of Vater, Neoplasms, Pancreatico¬duodenectomy, Radiotherapy


Ampullary carcinomas are rare malignancies representing less than 1% of all gastrointestinal cancers. Given the low incidence rate, there is scarcity of data regarding the survival benefit of the treatment options available. In the 2014 ASCO Gastrointestinal Cancers Symposium there were two abstracts that discussed the role of pancreaticoduodenectomy and adjuvant radiation therapy in ampullary carcinoma. The first study (Abstract #366) demonstrated a decline in morbidity and mortality over time for pancreaticoduodenectomy making it a reasonable option for successful treatment of ampullary carcinoma. The second study (Abstract #282) showed that adjuvant radiation therapy in patients with T2 tumors had improved median survival times compared to patients that did not receive radiation therapy.

Image: Morbidity, mortality, and survival of patients with peri-ampullary tumors who underwent pancreaticoduodenectomy (Figure 1)


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Morbidity, mortality, and survival of patients with peri-ampullary tumors who underwent pancreaticoduodenectomy
How to Cite
JohnP., KougioumtzopoulouA., SyrigosK., & SaifM. (2014). Updates in Management of Ampullary Carcinomas. JOP. Journal of the Pancreas, 15(2), 140-143. https://doi.org/10.6092/1590-8577/2283
Highlights from the “2014 ASCO Gastrointestinal Cancers Symposium”. San Francisco, CA, USA. January 16-18, 2014

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