Intraductal Oncocytic Papillary Neoplasm of the Pancreas: A Case of a Second Neoplasm in a Pancreas Cancer Survivor

  • Mrinal S Garg Division of Gastroenterology, Allegheny Health Network, Allegheny General Hospital. Pittsburgh, PA, USA
  • Theresa Schuerle Division of Gastroenterology, Allegheny Health Network, Allegheny General Hospital. Pittsburgh, PA, USA
  • Yulin Liu Division of Pathology, Allegheny Health Network, Allegheny General Hospital. Pittsburgh, PA, USA
  • Shyam J Thakkar Division of Gastroenterology, Allegheny Health Network, Allegheny General Hospital. Pittsburgh, PA, USA
Keywords: Carcinoma, Pancreatic Ductal, Cystadenocarcinoma, Mucinous, Neoplasms, Cystic, and Serous, Pancreas, Pancreatic Neoplasms

Abstract

Context Cystic neoplasms, which are less common forms of exocrine pancreatic neoplasms, consist of mainly intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms. Mucinous cystic neoplasms, unlike IPMN, are not associated with ductal growth, are usually multilocular in nature, and have ovarian type stroma. Mucinous cystadenocarcinoma is a type of mucinous cystic neoplasm more commonly found in women. Intraductal oncocytic papillary neoplasms of the pancreas are the least common variant of IPMN. Despite this classification, intraductal oncocytic papillary neoplasms have been compared to mucinous cystic neoplasms in previous studies and the classification is still questioned. Case report We report a rare case of an intraductal oncocytic papillary neoplasm of the pancreas occurring in a 52-year-old male with a prior history of surgically excised mucinous cystadenocarcinoma. This is the first known case of an intraductal oncocytic papillary neoplasm occurring after a prior pancreatic neoplasm. Conclusions As the diagnosis of intraductal oncocytic papillary neoplasms are rare, having only a few case reports and small series on which to understand its disease process, it is imperative to discuss each case and detail possible correlations with other pancreatic cystic neoplasms as well as distinctions from its current association within IPMN.

Image: Pathology of intraductal oncocytic papillary neoplasm.

Downloads

Download data is not yet available.

References

Adsay NV, Adair CF, Hessess CS, Klimistra DS. Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol 1996; 20: 980-984. [PMID: 8712298]

Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, et al. 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusettes General Hospital. Surgery 2012; 152:S4-12. [PMID: 22770958]

Wohlauer M, McManus M, Fukami N, Gajdos C. Intraductal oncocytic papillary neoplasm of the pancreas: report of a case requiring completion pancreatectomy. JOP 2013; 14: 77-80. [PMID: 23306340]

Oku T, Maeda M, Wada Y, Waga E, Ono K, et al. Intraductal oncocytic papillary neoplasm having clinical characteristics of mucinous cystic neoplasm and a benign histology. JOP 2007; 8: 206-213. [PMID: 17356245]

Liszka L, Pajak J, Zielinska E, Golka D, Mrowiec S, et al. Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature. Hepatobiliary Pancreat Sci 2010; 17: 246-261. [PMID: 20464560]

Fischer M, Donati O, et al. Intraductal oncocytic papillary neoplasm of the pancreas: A radio-pathological case study. JOP. 2010; 11: 49-54. [PMID: 20065553]

Jyotheesswaran S, Zotalis G, Penmetsa P, Levea CM, et al. A newly recognized entity: Intraductal oncocytic papillary neoplasm of the pancreas. Am J Gastroenterol 1998; 93: 2539-43. [PMID: 9860422]

Pathology of intraductal oncocytic papillary neoplasm
Published
2015-01-31
How to Cite
GargM., SchuerleT., LiuY., & ThakkarS. (2015). Intraductal Oncocytic Papillary Neoplasm of the Pancreas: A Case of a Second Neoplasm in a Pancreas Cancer Survivor. JOP. Journal of the Pancreas, 16(1), 63-65. https://doi.org/10.6092/1590-8577/2899
Section
CASE REPORTS