Biomarkers and Pharmacogenetics in Pancreatic Cancer

  • Xunhai Xu Division of Hematology and Oncology, Columbia University Medical Center. New York, NY, USA
  • Alexios S Strimpakos Oncology Unit, Third Department of Medicine, Sotiria General Hospital. Athens, Greece
  • Muhammad Wasif Saif Division of Hematology and Oncology, Columbia University Medical Center. New York, NY, USA
Keywords: Biological Markers, Biological Therapy, gemcitabine, Neoplastic Cells, Circulating, Pancreatic Neoplasms, Pharmacogenetics

Abstract

Appropriate identification and validation of biomarkers as well as pharmacogenetics are important in formulating patient-oriented, individualized chemotherapy or biological therapy in cancer patients. These markers can be especially valuable in pancreatic cancer, where high mortality and complex disease biology are frequently encountered. Recently, several advances have been made to further our knowledge in this specific area of pancreatic cancer. In the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting, researchers have presented several interesting results in biomarkers development: the identifications of 9 single nucleotide polymorphisms (SNPs) that is associated with positive efficacy of gemcitabine (Abstract #4022); the introduction of circulating tumor cells as a prognostic markers in pancreatic adenocarcinoma (Abstract #e14657); the re-affirmation of plasma cytidine deaminase (CDA) as a positive predictive markers for gemcitabine efficacy, as well as the postulations that CDA*3 as a potential genotype marker to predict gemcitabine responses (Abstract #e14645); and finally the retrospective tumor tissues analysis in the Arbeitsgemeinschaft Internistische Onkologie (AIO) trial in an attempt for epidermal growth factor receptor (EGFR) pathway biomarker identifications (Abstract #4047).

Image: Circulating tumor cells and process of metastasis (Detail. Copyright ©2002 from Molecular Biology of the Cell by Alberts et al. New York, NY, USA: Garland Sciences, 2002:132.

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Circulating tumor cells and process of metastasis (detail)
Published
2011-07-08
How to Cite
Xu, X., Strimpakos, A., & Saif, M. (2011). Biomarkers and Pharmacogenetics in Pancreatic Cancer. JOP. Journal of the Pancreas, 12(4), 325-329. https://doi.org/10.6092/1590-8577/3073
Section
Highlights from the “2011 ASCO Annual Meeting”. Chicago, IL, USA. June 3-7, 2011

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