Clinical Outcome of Pancreatic Cancer Patients with Diabetes Mellitus: Is Diabetes a Poor Prognostic Factor?
Diabetes mellitus and its related factors such as hyperinsulinemia have been linked to various cancer risks and outcomes. Previous research has offered inconsistent results in terms of relationship between diabetes and pancreatic cancers. Establishing clear association between these two entities may guide us in improving clinical outcomes of pancreatic cancer patients. Two abstracts that examined the association between diabetes mellitus and pancreatic cancer are updated in this paper. Herein, the authors report updated information from the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting in association between pancreatic cancer and diabetes mellitus. The present paper illustrates insufficient knowledge base to draw a conclusion in this topic. However, validation and understanding of the association could have significant clinical implications with respect to cancer prevention, early detection, and treatment. As such, further investigations are warranted to explore the link diabetes and pancreatic cancers.
Image: Department of Medicine, University of Chicago. Chicago, IL, USA.
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J Clin 2009; 59:225-49. [PMID 19474385]
Grote VA, Becker S, Kaaks R. Diabetes mellitus type 2: an independent risk factor for cancer? Exp Clin Endocrinol Diabetes 2010; 118:4-8. [PMID 20127570]
Tsugane S, Inoue M. Insulin resistance and cancer: epidemiological evidence. Cancer Sci 2010; 101:1073-9. [PMID 20345478]
Saruç M, Karaarslan M, Rasa K, Saygili O, Ince U, Baysal C, et al. Pancreatic cancer and glucose metabolism. Turk J Gastroenterol 2009; 20:257-60. [PMID 20084568]
Saruc M, Pour PM. Diabetes and its relationship to pancreatic carcinoma. Pancreas 2003; 26:381-7. [PMID 12717272]
Garg P, Gupta, R. Pancreatic cancer and diabetes: is diabetes a risk factor or the outcome? J Clin Oncol 2007; 25(18 Suppl):15123.
Busaidy N, Yazbeck C, Shah P, Evans D, Li D, Geraci JM, Weiser M. Survival of resectable pancreatic cancer patients with diabetes. J Clin Oncol 2006; 24(18 Suppl):4098.
Feng Y, Busaidy N, Yeung S. Differential impact of anti-diabetic treatment on pancreatic cancer cell growth in cell culture conditions mimicking different stages in the natural history of diabetes mellitus type 2. J Clin Oncol 2008; 26:(15 Suppl):4640.
Olowokure O, Beg MS, Ali S, Tandra A, Safa M, Havlin K, Ahmad SA. Is diabetes mellitus (DM) associated with worse outcomes in pancreatic cancer (PC)? J Clin Oncol 2010; 28(15 Suppl):4114.
Shama MA,Tanaka M, Curley SA, Abbruzzese JL, Li D. Association of diabetes with perineural invasion and overall survival in surgically resected patients with pancreatic cancer. J Clin Oncol 2010; 28(15 Suppl):4117.
Copyright (c) 2010 Soonmo Peter Kang, Muhammad Wasif Saif
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