Updates in Pancreatic Neuroendocrine Carcinoma

  • Susan Alsamarai Yale Cancer Center, Yale University School of Medicine. New Haven, CT, USA
  • Steven K Libutti Montefiore-Einstein Center for Cancer Care, Montefiore Medical Center, Albert Einstein College of Medicine. Bronx, NY, USA
  • Muhammad Wasif Saif Yale Cancer Center, Yale University School of Medicine. New Haven, CT, USA
Keywords: bevacizumab, mTOR protein, Neuroendocrine Tumors, sunitinib

Abstract

Pancreatic neuroendocrine tumors display a range of clinical presentations and outcomes. Surgical resection remains the only potentially curative approach for primary tumors, and is also associated with a survival benefit for hepatic metastases as well. Data presented at the American Society of Clinical Oncology (ASCO) Annual Meeting this year suggest that targeted agents may also play a role in advanced disease. Sunitinib, which targets VEGF-1, 2 and 3 and PDGF seems to be a well tolerated treatment for advanced tumors. The mTOR inhibitor everolimus when combined with the VEGF inhibitor bevacizumab, resulted in measurable responses. The combination of bevacizumab and cytotoxic chemotherapy also shows potential.

Image: Smilow Cancer Hospital at Yale. New Haven, CT, USA.

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Smilow Cancer Hospital at Yale. New Haven, CT, USA
Published
2010-07-05
How to Cite
AlsamaraiS., LibuttiS., & SaifM. (2010). Updates in Pancreatic Neuroendocrine Carcinoma. JOP. Journal of the Pancreas, 11(4), 336-340. https://doi.org/10.6092/1590-8577/3618
Section
Highlights from the “2010 ASCO Annual Meeting”. Chicago, IL, USA. June 4-8, 2010

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