Severe Acute Pancreatitis Due to Tamoxifen-Induced Hypertriglyceridemia with Positive Rechallenge

  • Jaballah Sakhri Research Unit 02SP09, Department of Surgery, Farhat Hached Hospital. Sousse, Tunisia
  • Chaker Ben Salem Department of Clinical Pharmacology, Faculty of Medicine of Sousse. Sousse, Tunisia
  • Houssem Harbi Research Unit 02SP09, Department of Surgery, Farhat Hached Hospital. Sousse, Tunisia
  • Neila Fathallah Department of Clinical Pharmacology, Faculty of Medicine of Sousse. Sousse, Tunisia
  • Rached Ltaief Research Unit 02SP09, Department of Surgery, Farhat Hached Hospital. Sousse, Tunisia
Keywords: Hypertriglyceridemia, Pancreatitis, Tamoxifen

Abstract

Context Pancreatitis is a very rare adverse effect of tamoxifen with only six cases of tamoxifen-associated pancreatitis reported in the English literature until now. In these cases, rechallenge with tamoxifen was not carried out. Case report We report a case of recurrent severe acute pancreatitis in a 44-year-old female induced by tamoxifen therapy and review the literature with regards to tamoxifen-associated pancreatitis. Conclusion Clinicians should be aware of the risks of developing severe acute pancreatitis when using tamoxifen therapy. If tamoxifen is suspected as the probable causative agent, rechallenge with this drug should be prohibited.

Image: Farhat Hached Hospital. Sousse, Tunisia.

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Farhat Hached Hospital. Sousse, Tunisia
Published
2010-07-05
How to Cite
SakhriJ., SalemC., HarbiH., FathallahN., & LtaiefR. (2010). Severe Acute Pancreatitis Due to Tamoxifen-Induced Hypertriglyceridemia with Positive Rechallenge. JOP. Journal of the Pancreas, 11(4), 382-384. https://doi.org/10.6092/1590-8577/3626
Section
CASE REPORTS

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