Wernicke Encephalopathy Presenting in a Patient with Severe Acute Pancreatitis

  • Ana Cecilia Arana-Guajardo Departamento de Medicina Interna. Hospital Universitario “Dr. José E. González”. Universidad Autónoma de Nuevo León. Monterrey, N.L. México. Madero y Gonzalitos S/N, Monterrey NL, Mexico.
  • Carlos Rodrigo Cámara-Lemarroy
  • Erick Joel Rendón- Ramírez
  • Joel Omar Jáquez-Quintana
  • Juan Fernando Góngora -Rivera
  • Dionicio Ángel Galarza-Delgado
Keywords: Pancreatitis, Thiamine, Wernicke Encephalopathy


Context Acute pancreatitis can lead to prolonged fasting and malnutrition. Many metabolic changes, including thiamine deficiency, may lead to the well know pancreatic encephalopathy. In this condition however the thiamine deficiency is rarely suspected. Case report We report the case of a 17-year-old woman with severe acute pancreatitis who developed mental status changes and ophthalmoplegia. A magnetic resonance image showed hyperintensive signals in periventricular areas, medial thalamus, and mammillary bodies, findings consistent with the diagnosis of Wernicke encephalopathy. Thiamine treatment reversed neurological complications. Conclusion Wernicke encephalopathy secondary to thiamine deficiency should be considered as a possible cause of acute mental status changes in patients with acute pancreatitis and malnutrition. Prophylactic doses of thiamine could be considered in susceptible patients.


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Bilateral and symmetrical hyperintense lesions in pulvinar and dorsomedial thalami
How to Cite
Arana-GuajardoA., Cámara-LemarroyC., Rendón- RamírezE., Jáquez-QuintanaJ., Góngora -RiveraJ., & Galarza-DelgadoD. (2012). Wernicke Encephalopathy Presenting in a Patient with Severe Acute Pancreatitis. JOP. Journal of the Pancreas, 13(1), 104-107. https://doi.org/10.6092/1590-8577/469