Preclinical Research in Treatment of Pancreatic Cancer

  • Evangelia Skoura Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital. Athens, Greece
  • Konstantinos N Syrigos Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital. Athens, Greece
  • Muhammad Wasif Saif Tufts University School of Medicine. Boston, MA, USA
Keywords: CDC7 protein, human, dactolisib, Drug Evaluation, Preclinical, Pancreatic Neoplasms


Pancreatic adenocarcinoma is an aggressive type of malignancy and remains a treatment-refractory cancer. Because of the few treatment options, understanding of the molecular mechanisms is necessary, for new drugs be developed against molecular targets. Two of the novel, promising regimens against molecular targets, NVP-BEZ235 and MSK-777, were examined in three preclinical studies performed in human pancreatic cell lines and mouse models and presented in the 2013 ASCO Annual Meeting. Two of the studies evaluated the role of NVP-BEZ235, an oral phosphatidylinositol-3-kinase (PI3K) inhibitor, in pancreatic cancer treatment, alone and in combination with nab-paclitaxel (Abstract #e15007) or gemcitabine (Abstract #e15070). The third study presents the effectiveness of the novel cell division cycle 7 (Cdc7) kinase inhibitor, MSK-777 (Abstract #e15059). All studies demonstrated promising results and further investigation is ongoing.

Image: PI3K-AKT-mTOR signalling pathway.


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PI3K-AKT-mTOR signalling pathway
How to Cite
SkouraE., SyrigosK., & SaifM. (2013). Preclinical Research in Treatment of Pancreatic Cancer. JOP. Journal of the Pancreas, 14(4), 384-387.
Highlights from the “2013 ASCO Annual Meeting”. Chicago, IL, USA. May 31 - June 4, 2013

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