Mitomycin-Induced Interstitial Pneumonitis in a Patient with BRCA2 Associated Metastatic Pancreatic Carcinoma

  • Muhammad Wasif Saif Yale University School of Medicine. New Haven, CT, USA
  • Tong Dai Yale University School of Medicine. New Haven, CT, USA
Keywords: Cryptogenic Organizing Pneumonia, Mitomycin, Pancreatic Neoplasms, Pneumonia


No abstract available.

Image: Space-filling model of the mitomycin molecule (Author: Jynto (talk); Wikimedia Commons)


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King TE Jr. Clinical advances in the diagnosis and therapy of the interstitial lung diseases. Am J Respir Crit Care Med 2005; 172:268-79. [PMID 15879420]

Chetta A, Marangio E, Olivieri D. Pulmonary function testing in interstitial lung diseases. Respiration 2004; 71:209-13. [PMID 15133338]

Camus P, Fanton A, Bonniaud P, Camus C, Foucher P. Interstitial lung disease induced by drugs and radiation. Respiration 2004; 71:301-26. [PMID 15316202]

Tulinius H, Egilsson V, Olafsdóttir GH, Sigvaldason H. Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer. BMJ 1992; 305:855-7. [PMID 1422397]

Phelan CM, Lancaster JM, Tonin P, Gumbs C, Cochran C, Carter R, et al. Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat Genet 1996; 13:120-2. [PMID 8673090]

Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst 1999; 91:1310-6. [PMID 10433620]

van der Heijden MS, Brody JR, Dezentje DA, Gallmeier E, Cunningham SC, Swartz MJ, et al. In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res 2005; 11:7508-15. [PMID 16243825]

van der Heijden MS, Brody JR, Gallmeier E, Cunningham SC, Dezentje DA, Shen D, et al. Functional defects in the fanconi anemia pathway in pancreatic cancer cells. Am J Pathol 2004; 165:651-7. [PMID 15277238]

Isacoff WH, Bendetti JK, Barstis JJ, Jazieh AR, Macdonald JS, Philip PA. Phase II trial of infusional fluorouracil, leucovorin, mitomycin, and dipyridamole in locally advanced unresectable pancreatic adenocarcinoma: SWOG S9700. J Clin Oncol 2007; 25:1665-9. [PMID 17470859]

Burch PA, Ghosh C, Schroeder G, Allmer C, Woodhouse CL, Goldberg RM, et al. Phase II evaluation of continuous-infusion 5-fluorouracil, leucovorin, mitomycin-C, and oral dipyridamole in advanced measurable pancreatic cancer: a North Central Cancer Treatment Group Trial. Am J Clin Oncol 2000; 23:534-7. [PMID 11039519]

Verweij J, van Zanten T, Souren T, Golding R, Pinedo HM. Prospective study on the dose relationship of mitomycin C-induced interstitial pneumonitis. Cancer 1987; 60:756-61. [PMID 3109726]

Linette DC, McGee KH, McFarland JA. Mitomycin-induced pulmonary toxicity: case report and review of the literature. Ann Pharmacother 1992; 26:481-4. [PMID 1576382]

Nadrous HF, Pellikka PA, Krowka MJ, Swanson KL, Chaowalit N, Decker PA, Ryu JH. Pulmonary hypertension in patients with idiopathic pulmonary fibrosis. Chest 2005; 128:2393-9. [PMID 16236900]

Carrero P, Garrote JA, Pacheco S, García AI, Gil R, Carbajosa SG. Report of six cases of human infection by Serratia plymuthica. J Clin Microbiol 1995; 33:275-6. [PMID 7714177]

Grohskopf LA, Roth VR, Feikin DR, Arduino MJ, Carson LA, Tokars JI, et al. Serratia liquefaciens bloodstream infections from contamination of epoetin alfa at a hemodialysis center. N Engl J Med 2001; 344:1491-7. [PMID 11357151]

Ursua PR, Unzaga MJ, Melero P, Iturburu I, Ezpeleta C, Cisterna R. Serratia rubidaea as an invasive pathogen. J Clin Microbiol 1996; 34:216-7. [PMID 8748310]

Su JR, Blossom DB, Chung W, Gullion JS, Pascoe N, Heseltine G, Srinivasan A. Epidemiologic investigation of a 2007 outbreak of Serratia marcescens bloodstream infection in Texas caused by contamination of syringes prefilled with heparin and saline. Infect Control Hosp Epidemiol 2009; 30:593-5. [PMID 19415967]

Makris D, Scherpereel A, Copin MC, Colin G, Brun L, Lafitte JJ, Marquette CH. Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer. BMC Cancer 2007 Aug 5; 7:150. [PMID 17683587]

Image: Space-filling model of the mitomycin molecule
How to Cite
SaifM., & DaiT. (2010). Mitomycin-Induced Interstitial Pneumonitis in a Patient with BRCA2 Associated Metastatic Pancreatic Carcinoma. JOP. Journal of the Pancreas, 11(3), 277-279.

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