Management of Skin Toxicities of Anti-EGFR Agents in Patients with Pancreatic Cancer and Other GI Tumors by Using Electronic Communication: Effective and Convenient

  • Muhammad Wasif Saif Yale University School of Medicine. New Haven, CT, USA
  • Kristin Kaley Yale University School of Medicine. New Haven, CT, USA
  • Lynne Lamb Yale University School of Medicine. New Haven, CT, USA
  • Jennifer Pecerillo Yale University School of Medicine. New Haven, CT, USA
  • Susan Hotchkiss Yale University School of Medicine. New Haven, CT, USA
  • Lisa Steven Yale University School of Medicine. New Haven, CT, USA
  • Marianne Brennan Yale University School of Medicine. New Haven, CT, USA
  • Robin Penney Yale University School of Medicine. New Haven, CT, USA
  • Carolyn Gillespie Yale University School of Medicine. New Haven, CT, USA
  • Walid Shaib Yale University School of Medicine. New Haven, CT, USA
Keywords: cetuximab, Drug Therapy, Epidermal Growth Factor, erlotinib, Pancreatic Neoplasms, panitumumab, Protein Kinase Inhibitors, Receptor


Erlotinib has been FDA approved to be used in combination with gemcitabine as the first line treatment in advanced pancreatic cancer patients. Skin rash has been documented as one of the commonest adverse reactions in patients receiving erlotinib and other EGFR inhibitors. Draw back to this reaction leads to: 1) drug discontinuation or dose reduction; 2) impairs quality of life; and 3) Puts patients at risk of superinfection. Monitoring patients closely and initiating immediate skin care is recommended. However, patients forget how the rash started and when. No standard treatments exist secondary to the diversity of symptoms, variability and intermittent occurrence in relation to the cancer therapy. In addition, there is slow improvement with medical treatment. Also, patients need to make extra visits to doctor’s office for skin management when in needed in addition to chemotherapy appointments. Late presentation for medical attention leading to complications, such as sepsis. We here experience a novel way of assessing and managing the skin rash using the electronic media. We suggest that electronic communication is of crucial importance to detect early, diagnose and treat anti-EGFR related skin rash in order to continue the benefit of anti-EGFR.

Image: Risk assessment and management algorithm.


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Risk assessment and management algorithm
How to Cite
SaifM., KaleyK., LambL., PecerilloJ., HotchkissS., StevenL., BrennanM., PenneyR., GillespieC., & ShaibW. (2010). Management of Skin Toxicities of Anti-EGFR Agents in Patients with Pancreatic Cancer and Other GI Tumors by Using Electronic Communication: Effective and Convenient. JOP. Journal of the Pancreas, 11(2), 176-182.

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