This Special Issue intended to wonder about how urban planning can contribute to reduce disparities due to the diversity of access to services, infrastructure and urban places, as well as the origin from a specific territorial area (center vs. periphery) and that could be accentuated by unforeseen global pandemics. Hence, contributions coming from scholars as well as from technicians have been collected around rethinking and redesigning territories and cities to support policy-makers in preventing and reducing socio-spatial inequalities.