The challenge that the complexity of the ongoing phenomena imposes on cities involves not only adopting mitigation measures aimed at reducing the adverse effects of these phenomena; this challenge requires scholars, researchers, technicians, and decision makers to transform cities into resilient competitive urban systems rapidly. The three issues of the 16th volume collect articles concerning the climatic, social, economic and health phenomena that have increasingly affected our cities in recent years and, hence, require the identification and implementation of adaptation actions to improve the resilience of urban systems.